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Telomere and telomerase in stem cells
https://hiroshima.repo.nii.ac.jp/records/2006537
https://hiroshima.repo.nii.ac.jp/records/200653745ee602e-2a73-49dc-b833-4ab03c065fde
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
BJC_96-7_1020.pdf (231.3 KB)
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| Item type | デフォルトアイテムタイプ_（フル）(1) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2023-03-18 | |||||||||
| タイトル | ||||||||||
| タイトル | Telomere and telomerase in stem cells | |||||||||
| 言語 | en | |||||||||
| 作成者 |
Hiyama, Eiso
× Hiyama, Eiso
× Hiyama, Keiko
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| アクセス権 | ||||||||||
| アクセス権 | open access | |||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||
| 権利情報 | ||||||||||
| 権利情報 | Copyright (c) 2007 Cancer Research UK | |||||||||
| 主題 | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | telomere | |||||||||
| 主題 | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | telomerase | |||||||||
| 主題 | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | stem cell | |||||||||
| 主題 | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | cancer stem cell | |||||||||
| 主題 | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | dyskeratosis congenita | |||||||||
| 主題 | ||||||||||
| 主題Scheme | NDC | |||||||||
| 主題 | 470 | |||||||||
| 内容記述 | ||||||||||
| 内容記述 | Telomeres, guanine-rich tandem DNA repeats of the chromosomal end, provide chromosomal stability, and cellular replication causes their loss. In somatic cells, the activity of telomerase, a reverse transcriptase that can elongate telomeric repeats, is usually diminished after birth so that the telomere length is gradually shortened with cell divisions, and triggers cellular senescence. In embryonic stem cells, telomerase is activated and maintains telomere length and cellular immortality; however, the level of telomerase activity is low or absent in the majority of stem cells regardless of their proliferative capacity. Thus, even in stem cells, except for embryonal stem cells and cancer stem cells, telomere shortening occurs during replicative aging, possibly at a slower rate than that in normal somatic cells. Recently, the importance of telomere maintenance in human stem cells has been highlighted by studies on dyskeratosis congenital, which is a genetic disorder in the human telomerase component. The regulation of telomere length and telomerase activity is a complex and dynamic process that is tightly linked to cell cycle regulation in human stem cells. Here we review the role of telomeres and telomerase in the function and capacity of the human stem cells. | |||||||||
| 言語 | en | |||||||||
| 出版者 | ||||||||||
| 出版者 | Nature Publishing Group | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | journal article | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | AO | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_b1a7d7d4d402bcce | |||||||||
| 関連情報 | ||||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | 10.1038/sj.bjc.6603671 | |||||||||
| 関連情報 | ||||||||||
| 識別子タイプ | PMID | |||||||||
| 関連識別子 | 17353922 | |||||||||
| 関連情報 | ||||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | http://dx.doi.org/10.1038/sj.bjc.6603671 | |||||||||
| 収録物識別子 | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 0007-0920 | |||||||||
| 収録物識別子 | ||||||||||
| 収録物識別子タイプ | NCID | |||||||||
| 収録物識別子 | AA00574355 | |||||||||
| 開始ページ | ||||||||||
| 開始ページ | 1020 | |||||||||
| 書誌情報 |
British Journal of Cancer British Journal of Cancer 巻 96, 号 7, p. 1020-1024, 発行日 2007 |
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| 旧ID | 20607 | |||||||||
