| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Chronic inhibition of the norepinephrine transporter in the brain participates in the seizure sensitization to cocaine and local anesthetics |
|
言語 |
en |
| 作成者 |
Arai, Shigeaki
Morita, Katsuya
Kitayama, Shigeo
Kumagai, Kei
Kumagai, Michiko
Kihira, Kenji
Dohi, Toshihiro
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
権利情報 |
Copyright (c) 2002 Elsevier Science B.V. |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Inhibition of monoamine transporters |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Seizure |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Kindling |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Local anesthetics |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Cocaine |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
|
|
内容記述 |
Involvement of chronic inhibition of monoamine transporters (MAT) in the brain concerning the sensitization of cocaine- and local anesthetic-induced seizures was studied in mice. Repeated administration of subconvulsive doses of meprylcaine as well as cocaine, both of which inhibit MAT, but not lidocaine, which does not inhibit MAT, increased seizure activity and produced sensitization to other local anesthetics. Effects of 5 daily treatments of monoamine transporter inhibitors on lidocaine-induced convulsions were examined 2 or 3 days after the last dose of the inhibitors. The daily treatments of GBR 12935, a specific inhibitor of dopamine uptake, significantly increased the incidence and the intensity of lidocaine-induced convulsions at 20 mg/kg and decreased the threshold of the convulsions. The daily treatments of desipramine and maprotiline, selective norepinephrine uptake inhibitors, markedly increased the incidence and intensity of lidocaine-induced convulsions, and decreased the threshold with dose-dependent manner between 5 and 20 mg/kg. The daily treatments of citaloplam, a selective serotonin uptake inhibitor, 10 and 20 mg/kg, produced no significant increase in the incidence or intensity of lidocaine-induced convulsions but decreased the threshold of the convulsions. These results suggest that the chronic intermittent inhibition of monoamine uptake increases susceptibility to cocaine- and local anesthetic-induced seizures, and a norepinephrine transporter is an integral component of this sensitization. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Elsevier Science B.V. |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
AO |
|
出版タイプResource |
http://purl.org/coar/version/c_b1a7d7d4d402bcce |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1016/S0006-8993(02)04068-4 |
| 関連情報 |
|
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
12573515 |
| 関連情報 |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
http://dx.doi.org/10.1016/S0006-8993(02)04068-4 |
| 開始ページ |
|
|
開始ページ |
83 |
| 書誌情報 |
Brain research
Brain research
巻 964,
号 1,
p. 83-90,
発行日 2003-02-21
|
| 旧ID |
113 |
Brain-Res_964-1_83-90_2003-2-21.pdf (267.9 KB)
