| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Inhibition of serotonin transporters by cocaine and meprylcaine |
|
言語 |
en |
| 作成者 |
Morita, Katsuya
Hamamoto, Masahiro
Arai, Shigeaki
Kitayama, Shigeo
Irifune, Masahiro
Kawahara, Michio
Kihira, Kenji
Dohi, Toshihiro
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
権利情報 |
Copyright (c) 2005 Elsevier B.V |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Serotonin transporter |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Convulsion |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
SSRI |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Cocaine |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Local anesthetics |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
|
|
内容記述 |
The present study examined whether the inhibition of serotonin transporters (SERT) contributes to cocaine- and other local anesthetics-induced convulsions, and which subtypes of 5-HT receptor are involved in the convulsions. For this purpose, cocaine, meprylcaine and lidocaine, all of which have different effects on SERT, were used as convulsants and the effects of serotonin reuptake inhibitors (SSRIs), specific agonists and antagonists for 5-HT receptor subtypes were evaluated in mice.Administration of SSRI, zimelidine, citalopram and fluoxetine, 5-HT2A,2C receptor agonist, R(-)-DOI and the 5-HT2C receptor agonists, mCPP and MK212 resulted in a marked increase in incidence of convulsions and a reduction in the threshold of lidocaine-induced convulsions, while the 5-HT2B receptor agonist, BW723C86, had little influence. On the other hand, SSRI did not affect the measured parameters in meprylcaine- and cocaine-induced convulsions. R(-)-DOI, mCPP and MK212 reduced the threshold of meprylcaine or cocaine with less extent than the reduction of lidocaine threshold. Incidence of cocaine- and meprylcaine-induced convulsions were significantly reduced by 5-HT2A,2B,2C antagonist, LY-53857 and 5-HT2C antagonist, RS 102221. The threshold of cocaine and meprylcaine was significantly increased by both antagonists. 5-HT2A antagonists MDL-11,939 and ketanserin, and 5-HT2B antagonist SB-204741 except at high doses had little effect on cocaine- and meprylcaine-induced convulsions. None of these antagonists altered the parameters of lidocaine-induced convulsions. Pretreatment with fluoxetine but not citalopram increased the plasma concentration of lidocaine. These results suggest that the increase of serotonergic neuronal activity through 5-HT2C receptor stimulation was responsible for increased activity of local anesthetics-induced convulsions and support the involvement of this mechanism in cocaine- and meprylcaine- but not in lidocaine- induced convulsions through their direct inhibitory action on central SERT. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Elsevier B.V |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
AO |
|
出版タイプResource |
http://purl.org/coar/version/c_b1a7d7d4d402bcce |
| 関連情報 |
|
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
16125150 |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1016/j.brainres.2005.07.049 |
| 関連情報 |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
http://dx.doi.org/10.1016/j.brainres.2005.07.049 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0361-0713 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA0057324X |
| 開始ページ |
|
|
開始ページ |
153 |
| 書誌情報 |
Brain Research
Brain Research
巻 1057,
号 1-2,
p. 153-160,
発行日 2005-09-28
|
| 旧ID |
115 |
Brain-Res_1057-1-2_153-160_2005-9-28.pdf (254.7 KB)
