| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2024-12-18 |
| タイトル |
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|
タイトル |
Role of sclerostin deletion in bisphosphonate-induced osteonecrosis of the jaw |
|
言語 |
en |
| 作成者 |
Nakashima, Fuminori
Matsuda, Shinji
Ninomiya, Yurika
Ueda, Tomoya
Yasuda, Keisuke
Hatano, Saki
Shimada, Shogo
Furutama, Daisuke
Memida, Takumi
Kajiya, Mikihito
Shukunami, Chisa
Ouhara, Kazuhisa
Mizuno, Noriyoshi
|
| アクセス権 |
|
|
アクセス権 |
embargoed access |
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アクセス権URI |
http://purl.org/coar/access_right/c_f1cf |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
© 2024. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
This is not the published version. Please cite only the published version. |
| 権利情報 |
|
|
言語 |
ja |
|
権利情報 |
この論文は出版社版ではありません。引用の際には出版社版をご確認、ご利用ください。 |
| 主題 |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Medication-induced related osteonecrosis of the jaw |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Sclerostin |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Bone formation |
| 主題 |
|
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言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Extraction socket healing |
| 内容記述 |
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|
内容記述 |
Purpose Bone resorption inhibitors, such as bisphosphonates (BP) and denosumab, are frequently used for the management of osteoporosis. Although both drugs reduce the risk of osteoporotic fractures, they are associated with a serious side effect known as medication-related osteonecrosis of the jaw (MRONJ). Sclerostin antibodies (romosozumab) increase bone formation and decrease the risk of osteoporotic fractures: however, their anti-resorptive effect increases ONJ. Thus, this study aimed to elucidate the role of sclerostin deletion in the development of MRONJ. Methods Sclerostin knockout (SostΔ26/Δ26) mice were used to confirm the development of ONJ by performing tooth extractions. To confirm the role of sclerostin deficiency in a more ONJ-prone situation, we used the BP-induced ONJ model in combination with severe periodontitis to evaluate the development of ONJ and bone formation in wild-type (WT) and SostΔ26/Δ26 mice. Wound healing assay using gingival fibroblasts with or without sclerostin stimulation and tooth extraction socket healing were evaluated in the WT and SostΔ26/Δ26 mice. Results ONJ was not detected in the extraction socket of SostΔ26/Δ26 mice. Moreover, the incidence of ONJ was significantly lower in the SostΔ26/Δ26 mice treated with BP compared to that of the WT mice. Osteogenic proteins, osteocalcin, and runt-related transcription factor 2, were expressed in the bone surface in SostΔ26/Δ26 mice. Recombinant sclerostin inhibited gingival fibroblast migration. The wound healing rate of the extraction socket was faster in SostΔ26/Δ26 mice than in WT mice. Conclusion Sclerostin deficiency did not cause ONJ and reduced the risk of developing BP-induced ONJ. Enhanced bone formation and wound healing were observed in the tooth extraction socket. The use of romosozumab (anti-sclerostin antibody) has proven to be safe for surgical procedures of the jaw. |
|
言語 |
en |
| 出版者 |
|
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出版者 |
Elsevier |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 関連情報 |
|
|
関連タイプ |
isVersionOf |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.1016/j.bone.2024.117200 |
| 助成情報 |
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助成機関名 |
日本学術振興会 |
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言語 |
ja |
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研究課題番号URI |
https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-23K15973/ |
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研究課題番号 |
23K15973 |
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研究課題名 |
ロモソズマブによる顎骨壊死発症の検証およびそのメカニズム解明の研究 |
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言語 |
ja |
| 助成情報 |
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助成機関名 |
Japan Society for the Promotion of Science |
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言語 |
en |
|
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研究課題番号 |
JPMJSP2132 |
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研究課題名 |
ロモソズマブによる顎骨壊死発症の検証およびそのメカニズム解明の研究 |
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言語 |
ja |
| 助成情報 |
|
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助成機関名 |
科学技術振興機構 |
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言語 |
ja |
|
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研究課題名 |
広島大学創発的 次世代 研究者育成・支援プログラム |
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言語 |
ja |
| 助成情報 |
|
|
|
助成機関名 |
Japan Science and Technology Agency |
|
|
言語 |
en |
|
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研究課題名 |
広島大学創発的 次世代 研究者育成・支援プログラム |
|
|
言語 |
ja |
| 開始ページ |
|
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開始ページ |
117200 |
| 書誌情報 |
en : Bone
巻 187,
p. 117200,
発行日 2024-07-15
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| 旧ID |
55876 |
| 備考 |
The full-text file will be made open to the public on 15 July 2025 in accordance with publisher's 'Terms and Conditions for Self-Archiving' |
Bone_187_117200.pdf (3.3 MB)
