| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
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|
タイトル |
Evidence for association between the HLA-DQA locus and abdominal aortic aneurysms in the Belgian population : a case control study |
|
言語 |
en |
| 作成者 |
Ogata, Toru
Gregoire, Lucie
Goddard, Katrina AB
Skunca, Magdalena
Tromp, Gerard
Lancaster, Wayne D
Parrado, Antonio R
Lu, Qing
Shibamura, Hidenori
Sakalihasan, Natzi
Limet, Raymond
MacKean, Gerald L
Arthur, Claudette
Sueda, Taijiro
Kuivaniemi, Helena
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| アクセス権 |
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|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
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|
権利情報 |
Copyright (c) 2006 Ogata et al; licensee BioMed Central Ltd. |
| 主題 |
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主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
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|
内容記述 |
Background: Chronic inflammation and autoimmunity likely contribute to the pathogenesis of abdominal aortic aneurysms (AAAs). The aim of this study was to investigate the role of autoimmunity in the etiology of AAAs using a genetic association study approach with HLA polymorphisms. Methods: HLA-DQA1, -DQB1, -DRB1 and -DRB3-5 alleles were determined in 387 AAA cases (180 Belgian and 207 Canadian) and 426 controls (269 Belgian and 157 Canadian) by a PCR and single-strand oligonucleotide probe hybridization assay. Results: We observed a potential association with the HLA-DQA1 locus among Belgian males (empirical p = 0.027, asymptotic p = 0.071). Specifically, there was a significant difference in the HLA-DQA1*0102 allele frequencies between AAA cases (67/322 alleles, 20.8%) and controls (44/356 alleles, 12.4%) in Belgian males (empirical p = 0.019, asymptotic p = 0.003). In haplotype analyses, marginally significant association was found between AAA and haplotype HLA-DQA1-DRB1 (p = 0.049 with global score statistics and p = 0.002 with haplotype-specific score statistics). Conclusion: This study showed potential evidence that the HLA-DQA1 locus harbors a genetic risk factor for AAAs suggesting that autoimmunity plays a role in the pathogenesis of AAAs. |
|
言語 |
en |
| 出版者 |
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出版者 |
BioMed Central |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
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|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連情報 |
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|
識別子タイプ |
DOI |
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関連識別子 |
10.1186/1471-2350-7-67 |
| 関連情報 |
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|
識別子タイプ |
PMID |
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関連識別子 |
16879749 |
| 関連情報 |
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
http://dx.doi.org/10.1186/1471-2350-7-67 |
| 収録物識別子 |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1471-2350 |
| 収録物識別子 |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12035063 |
| 開始ページ |
|
|
開始ページ |
67 |
| 書誌情報 |
BMC Medical Genetics
BMC Medical Genetics
巻 7,
p. 67,
発行日 2006-07-31
|
| 旧ID |
17221 |
BMCMedGen_7_67.pdf (326.1 KB)
