| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
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|
タイトル |
Differences in K-ras and mitochondrial DNA mutations and microsatellite instability between colorectal cancers of Vietnamese and Japanese patients |
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言語 |
en |
| 作成者 |
Miwata, Tomohiro
Hiyama, Tooru
Trong Quach, Duc
Le, Huy Minh
Thi, Hua Ha Ngoc
Oka, Shirou
Tanaka, Shinji
Arihiro, Kouji
Chayama, Kazuaki
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| アクセス権 |
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アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
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権利情報 |
© 2014 Miwata et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Colorectal cancer |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Vietnamese |
| 主題 |
|
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主題Scheme |
Other |
|
主題 |
Japanese |
| 主題 |
|
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主題Scheme |
Other |
|
主題 |
K-ras |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Mitochondrial DNA |
| 主題 |
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主題Scheme |
Other |
|
主題 |
Microsatellite instability |
| 主題 |
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|
主題Scheme |
Other |
|
主題 |
D310 |
| 主題 |
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|
主題Scheme |
Other |
|
主題 |
BAT-26 |
| 主題 |
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主題Scheme |
Other |
|
主題 |
Mutation |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
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|
内容記述 |
[Background]:The incidence of early-onset (under 50 years of age) colorectal cancer (CRC) in the Vietnamese has been reported to be quite higher than that in the Japanese. To clarify the differences in genetic alterations between Vietnamese and Japanese CRCs, we investigated mutations in K-ras and mitochondrial DNA (mtDNA) and high-frequency microsatellite instability (MSI-H) in the CRCs of Vietnamese and Japanese patients. [Methods]:We enrolled 60 Vietnamese and 233 Japanese patients with invasive CRCs. DNA was extracted from formalin-fixed, paraffin-embedded tissue sections. K-ras mutations were examined with PCR-single-strand conformation polymorphism analysis. mtDNA mutations and MSI-H were examined with microsatellite analysis using D310 and BAT-26, respectively. [Results]:K-ras mutations were examined in 60 Vietnamese and 45 Japanese CRCs. The frequency of the mutations in the Vietnamese CRCs was significantly higher than that in the Japanese CRCs (8 of 24 [33%] vs 5 of 45 [11%], p =0.048). MSI-H was examined in 60 Vietnamese and 130 Japanese CRCs. The frequency of MSI-H in the Vietnamese CRCs was also significantly higher than that in the Japanese CRCs (6 of 27 [22%] vs 10 of 130 [8%], p =0.030). mtDNA mutations were examined in 60 Vietnamese and 138 Japanese CRCs. The frequency of mtDNA mutations in the Vietnamese CRCs was significantly higher than that in the Japanese CRCs (19 of 44 [43%] vs 11 of 133 [9%], p <0.001). There were no significant differences in clinicopathologic characteristics, such as age, sex, tumour location, and depth, in terms of tumours with/without each genetic alteration in the CRCs of the Vietnamese and Japanese patients. [Conclusions]:These results indicate that the developmental pathways of CRCs in the Vietnamese may differ from those of CRCs in the Japanese. |
|
言語 |
en |
| 出版者 |
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出版者 |
BioMed Central |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連情報 |
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|
識別子タイプ |
DOI |
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関連識別子 |
10.1186/s12876-014-0203-0 |
| 関連情報 |
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|
識別子タイプ |
PMID |
|
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関連識別子 |
25433803 |
| 関連情報 |
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1186/s12876-014-0203-0 |
| 収録物識別子 |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1471-230X |
| 開始ページ |
|
|
開始ページ |
203 |
| 書誌情報 |
BMC Gastroenterology
BMC Gastroenterology
巻 14,
p. 203,
発行日 2014-11-30
|
| 旧ID |
47120 |
bmcg_14_203.pdf (351.3 KB)
