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Altered expression of a putative progenitor cell marker DCAMKL1 in the rat gastric mucosa in regeneration, metaplasia and dysplasia

https://hiroshima.repo.nii.ac.jp/records/2006509
https://hiroshima.repo.nii.ac.jp/records/2006509
786389be-1ec2-4eca-bac7-e2fa4defc2c2
名前 / ファイル ライセンス アクション
BMCGastroenterol_10_65.pdf BMCGastroenterol_10_65.pdf (4.1 MB)
Item type デフォルトアイテムタイプ_(フル)(1)
公開日 2023-03-18
タイトル
タイトル Altered expression of a putative progenitor cell marker DCAMKL1 in the rat gastric mucosa in regeneration, metaplasia and dysplasia
言語 en
作成者 Kikuchi, Miho

× Kikuchi, Miho

en Kikuchi, Miho

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Nagata, Hiroshi

× Nagata, Hiroshi

en Nagata, Hiroshi

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Watanabe, Norihito

× Watanabe, Norihito

en Watanabe, Norihito

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Watanabe, Hiromitsu

× Watanabe, Hiromitsu

en Watanabe, Hiromitsu

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Tatemichi, Masayuki

× Tatemichi, Masayuki

en Tatemichi, Masayuki

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Hibi, Toshifumi

× Hibi, Toshifumi

en Hibi, Toshifumi

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
権利情報 Copyright (c) 2010 Kikuchi et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
主題
主題Scheme NDC
主題 490
内容記述
内容記述 Background: Doublecortin and calcium/calmodulin-dependent protein kinase-like-1 (DCAMKL1) is a candidate marker for progenitor cells in the gastrointestinal mucosa. Lineage cells in the gastric mucosa are derived from progenitor cells, but this process can be altered after injury. Therefore, we explored DCAMKL1 expression under pathological conditions. Methods: An immunohistochemical analysis was performed in rat stomach with acute superficial injury, chronic ulcer, intestinal metaplasia and dysplasia. Results: DCAMKL1 was exclusively expressed in immature quiescent cells in the isthmus of normal fundic glands, where putative progenitor cells are thought to reside. DCAMKL1-positive cells and proliferating cells shed into the lumen after superficial injury and re-appeared during the regenerative process, mainly in the superficial mucosa. In the marginal mucosa around the active ulcer, parietal and chief cells diminished, foveolar hyperplasia was evident, and trefoil factor family 2 (TFF2)/spasmolytic polypeptide-expressing metaplasia (SPEM) emerged at the gland base. DCAMKL1 cells re-emerged in the deep mucosa juxtaposed with SPEM and proliferating cells. In the healing ulcer, the TFF2 cell population expanded and seemed to redifferentiate to chief cells, while proliferating cells and DCAMKL1 cells appeared above and below the TFF2 cells to promote healing. SPEM appeared and PCNA cells increased in the intestinalized mucosa, and DCAMKL1 was expressed in the proximity of the PCNA cells in the deep mucosa. DCAMKL1, PCNA and TFF2 were expressed in different dysplastic cells lining dilated glands near SPEM. Conclusion: The ultrastructural appearance of DCAMKL1-positive cells and the expression patterns of DCAMKL1 in normal and pathological states indicate that the cells belong to a progenitor cell population. DCAMKL1 expression is closely associated with TFF2/SPEM cells after injury. DCAMKL1 cells repopulate close to proliferating, hyperplastic, metaplastic and dysplastic cells, and the progenitor zone shifts according to the pathological circumstances.
言語 en
出版者
出版者 BioMed Central Ltd
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
関連情報
識別子タイプ DOI
関連識別子 10.1186/1471-230X-10-65
関連情報
識別子タイプ DOI
関連識別子 http://dx.doi.org/10.1186/1471-230X-10-65
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1471-230X
収録物識別子
収録物識別子タイプ NCID
収録物識別子 AA12034934
開始ページ
開始ページ 65-1
書誌情報 BMC Gastroenterology
BMC Gastroenterology

巻 10, p. 65-1-65-14, 発行日 2010-06-18
旧ID 30816
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