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Mechanistic target of rapamycin complex 1 signaling regulates cell proliferation, cell survival, and differentiation in regenerating zebrafish fins

https://hiroshima.repo.nii.ac.jp/records/2006507
https://hiroshima.repo.nii.ac.jp/records/2006507
7a114d3f-054a-4202-a54f-7f49531dadcc
名前 / ファイル ライセンス アクション
bmcdb_14_42.pdf bmcdb_14_42.pdf (4.1 MB)
Item type デフォルトアイテムタイプ_(フル)(1)
公開日 2023-03-18
タイトル
タイトル Mechanistic target of rapamycin complex 1 signaling regulates cell proliferation, cell survival, and differentiation in regenerating zebrafish fins
言語 en
作成者 Hirose, Kentaro

× Hirose, Kentaro

en Hirose, Kentaro

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Shiomi, Taishi

× Shiomi, Taishi

en Shiomi, Taishi

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Hozumi, Shunya

× Hozumi, Shunya

en Hozumi, Shunya

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Kikuchi, Yutaka

× Kikuchi, Yutaka

en Kikuchi, Yutaka

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
権利情報 © 2014 Hirose et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
主題
主題Scheme Other
主題 Mechanistic target of rapamycin
主題
主題Scheme Other
主題 Fin
主題
主題Scheme Other
主題 Regeneration
主題
主題Scheme Other
主題 Zebrafish
主題
主題Scheme Other
主題 Osteoblast
主題
主題Scheme Other
主題 Cell proliferation
主題
主題Scheme Other
主題 Cell survival
主題
主題Scheme Other
主題 Differentiation
主題
主題Scheme NDC
主題 460
内容記述
内容記述 [Background]:The mechanistic target of rapamycin complex1 (mTORC1) signaling pathway has been implicated in functions of multicellular processes, including cell growth and metabolism. Although recent reports showed that many signaling pathways, including Activin, Bmp, Fgf, sonic hedgehog, Insulin-like growth factor (IGF), Notch, retinoic acid, and Wnt, are implicated in non-mammalian vertebrate regeneration, also known as epimorphic regeneration, mTORC1 function remains unknown. [Results]:To investigate the role of mTORC1 signaling pathway in zebrafish caudal fin, we examined the activation and function of mTORC1 signaling using an antibody against phosphorylated S6 kinase and a specific inhibitor, rapamycin. mTORC1 signaling is activated in proliferative cells of intra-ray and wound epidermal cells before blastema formation, as well as in proliferative blastema cells, wound epidermal cells, and osteoblasts during regenerative outgrowth. Before blastema formation, proliferation of intra-ray and wound epidermal cells is suppressed, but cell death is not affected by mTORC1 signaling inhibition with rapamycin. Moreover, rapamycin treatment inhibits blastema and wound epidermal cell proliferation and survival during blastema formation and regenerative outgrowth, as well as osteoblast proliferation and differentiation during regenerative outgrowth. We further determined that mTORC1 signaling is regulated through IGF-1 receptor/phosphatidylinositol-3 kinase and Wnt pathways during fin regeneration. [Conclusion]:Taken together, our findings reveal that mTORC1 signaling regulates proliferation, survival, and differentiation of intra-ray cells, wound epidermis, blastema cells, and/or osteoblasts in various fin regeneration stages downstream of IGF and Wnt signaling pathways.
言語 en
内容記述
内容記述タイプ Other
内容記述 This study was supported by grants from Grant-in-Aid for Scientific Research from the JSPS (KAKENHI 23616002) to Y.K., and from Hiroshima University Alumni Association Research Grant & Hiroshima University Support Foundation Research and Grant-in-Aid for Scientific Research from the JSPS (KAKENHI 26 · 6771) to K.H.
出版者
出版者 BioMed Central
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
関連情報
識別子タイプ DOI
関連識別子 10.1186/s12861-014-0042-9
関連情報
識別子タイプ PMID
関連識別子 25480380
関連情報
識別子タイプ DOI
関連識別子 https://doi.org/10.1186/s12861-014-0042-9
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1471-213X
開始ページ
開始ページ 42
書誌情報 BMC Developmental Biology
BMC Developmental Biology

巻 14, p. 42, 発行日 2014-12-06
旧ID 47119
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