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Effects of acute ethanol intoxication in an ovine peritonitis model

https://hiroshima.repo.nii.ac.jp/records/2006501
https://hiroshima.repo.nii.ac.jp/records/2006501
b7b693f1-35b0-4f6e-9b3f-ac3f2ff6d717
名前 / ファイル ライセンス アクション
bmca_18_70.pdf bmca_18_70.pdf (679.5 KB)
Item type デフォルトアイテムタイプ_(フル)(1)
公開日 2023-03-18
タイトル
タイトル Effects of acute ethanol intoxication in an ovine peritonitis model
言語 en
作成者 Hosokawa, Koji

× Hosokawa, Koji

en Hosokawa, Koji

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Su, Fuhong

× Su, Fuhong

en Su, Fuhong

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Silvio Taccone, Fabio

× Silvio Taccone, Fabio

en Silvio Taccone, Fabio

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Creteur, Jacques

× Creteur, Jacques

en Creteur, Jacques

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Vincent, Jean-Louis

× Vincent, Jean-Louis

en Vincent, Jean-Louis

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
権利情報 © The Author(s). 2018. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
主題
主題Scheme Other
主題 Ethanol intoxication
主題
主題Scheme Other
主題 Sepsis
主題
主題Scheme Other
主題 Septic shock
主題
主題Scheme Other
主題 Renal blood flow
主題
主題Scheme Other
主題 Brain perfusion
主題
主題Scheme Other
主題 Lactate/pyruvate
主題
主題Scheme NDC
主題 490
内容記述
内容記述 [Background] Acute ethanol intoxication has been shown to have contrasting effects on outcomes in sepsis. The aim of this study was to explore the effects of acute ethanol intoxication on hemodynamics, renal function, brain perfusion and lactate/pyruvate in an ovine sepsis model. [Methods] Anesthetized, mechanically ventilated female sheep were randomized to an ethanol group (n = 7), which received 1 g/kg ethanol diluted in intravenous (i.v.) saline infusion or a control group (n = 7), which received the same volume of i.v. saline. Both groups received the treatment for a period of 2 h prior to induction of sepsis by intraperitoneal injection of feces. Other treatment included fluid resuscitation but no vasopressors or antibiotics. Global hemodynamics, renal blood flow, brain cortex laser Doppler flowmetry and microdialysis analyses were recorded hourly. [Results] In the ethanol group, blood ethanol concentrations were 137 ± 29 mg/dL at the time of feces injection and decreased to become undetectable by 12 h. Arterial hypotension occurred earlier in the ethanol than in the control group (8 [7–12] vs. 14 [11–20] hours, p = 0.03). Lactate levels increased to > 2 mmol/L earlier in the ethanol group. Renal dysfunction (9 [6–13] vs. 13 [12–15] hours, p = 0.05) and oliguria (urine output < 0.5 mL/kg/h; 10 [7–12] vs. 13 [12, 13] hours, p = 0.01) developed earlier in the ethanol than in the control group. Brain blood flow and lactate/pyruvate were unaffected. There was no significant difference in survival time. [Conclusions] Acute ethanol intoxication in this model of peritonitis resulted in earlier development of shock and renal dysfunction but did not alter brain perfusion and metabolism or short-term survival.
言語 en
出版者
出版者 Springer Nature
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
関連情報
識別子タイプ DOI
関連識別子 10.1186/s12871-018-0537-1
関連情報
識別子タイプ PMID
関連識別子 29921225
関連情報
識別子タイプ DOI
関連識別子 https://doi.org/10.1186/s12871-018-0537-1
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1471-2253
開始ページ
開始ページ 70
書誌情報 BMC Anesthesiology
BMC Anesthesiology

巻 18, p. 70, 発行日 2018-06-19
旧ID 47066
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