| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
A role for planar cell polarity during early endoderm morphogenesis |
|
言語 |
en |
| 作成者 |
Miles, Lee B.
Mizoguchi, Takamasa
Kikuchi, Yutaka
Verkade, Heather
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
権利情報 |
© 2017. Published by The Company of Biologists Ltd., This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Endoderm |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Planar cell polarity (PCP) |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Zebrafish |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
midline aggregation |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Development |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
460 |
| 内容記述 |
|
|
内容記述 |
The zebrafish endoderm begins to develop at gastrulation stages as a monolayer of cells. The behaviour of the endoderm during gastrulation stages is well understood. However, knowledge of the morphogenic movements of the endoderm during somitogenesis stages, as it forms a mesenchymal rod, is lacking. Here we characterise endodermal development during somitogenesis stages, and describe the morphogenic movements as the endoderm transitions from a monolayer of cells into a mesenchymal endodermal rod. We demonstrate that, unlike the overlying mesoderm, endodermal cells are not polarised during their migration to the midline at early somitogenesis stages. Specifically, we describe the stage at which endodermal cells begin to leave the monolayer, a process we have termed ‘midline aggregation’. The planar cell polarity (PCP) signalling pathway is known to regulate mesodermal and ectodermal cell convergence towards the dorsal midline. However, a role for PCP signalling in endoderm migration to the midline during somitogenesis stages has not been established. In this report, we investigate the role for PCP signalling in multiple phases of endoderm development during somitogenesis stages. Our data exclude involvement of PCP signalling in endodermal cells as they leave the monolayer. |
|
言語 |
en |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
The work was supported by a project grant from the National Health and Medical Research Council (491087) to H.V. |
| 出版者 |
|
|
出版者 |
The Company of Biologists Ltd. |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1242/bio.021899 |
| 関連情報 |
|
|
|
識別子タイプ |
URI |
|
|
関連識別子 |
http://bio.biologists.org/content/6/5/531 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
2046-6390 |
| 開始ページ |
|
|
開始ページ |
531 |
| 書誌情報 |
Biology Open
Biology Open
巻 6,
p. 531-539,
発行日 2017-03
|
| 旧ID |
46875 |
531.full.pdf (1.7 MB)
