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Nephrotoxicity Induced by Piperacillin–Tazobactam in Late Elderly Japanese Patients with Nursing and Healthcare Associated Pneumonia

https://hiroshima.repo.nii.ac.jp/records/2006475
https://hiroshima.repo.nii.ac.jp/records/2006475
7122fd04-ca21-4b76-8475-a76a15391f00
名前 / ファイル ライセンス アクション
BiolPharmBull_37_1971.pdf BiolPharmBull_37_1971.pdf (305.3 KB)
Item type デフォルトアイテムタイプ_(フル)(1)
公開日 2023-03-18
タイトル
タイトル Nephrotoxicity Induced by Piperacillin–Tazobactam in Late Elderly Japanese Patients with Nursing and Healthcare Associated Pneumonia
言語 en
作成者 Karino, Fumi

× Karino, Fumi

en Karino, Fumi

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Nishimura, Nobuhiro

× Nishimura, Nobuhiro

en Nishimura, Nobuhiro

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Ishihara, Noriyuki

× Ishihara, Noriyuki

en Ishihara, Noriyuki

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Moriyama, Hidehiko

× Moriyama, Hidehiko

en Moriyama, Hidehiko

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Miura, Kiyotaka

× Miura, Kiyotaka

en Miura, Kiyotaka

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Hamaguchi, Shunichi

× Hamaguchi, Shunichi

en Hamaguchi, Shunichi

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Sutani, Akihisa

× Sutani, Akihisa

en Sutani, Akihisa

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Kuraki, Takashige

× Kuraki, Takashige

en Kuraki, Takashige

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Ikawa, Kazuro

× Ikawa, Kazuro

en Ikawa, Kazuro

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Morikawa, Norifumi

× Morikawa, Norifumi

en Morikawa, Norifumi

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Naora, Kohji

× Naora, Kohji

en Naora, Kohji

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Isobe, Takeshi

× Isobe, Takeshi

en Isobe, Takeshi

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
権利情報 Copyright (c) 2014 The Pharmaceutical Society of Japan
主題
主題Scheme Other
主題 piperacillin–tazobactam
主題
主題Scheme Other
主題 Japanese late elderly patient
主題
主題Scheme Other
主題 nephrotoxicity
主題
主題Scheme Other
主題 nursing and healthcare associated pneumonia
主題
主題Scheme NDC
主題 490
内容記述
内容記述 This study aimed to clarify the efficacy, safety, and pharmacokinetics of piperacillin-tazobactam (PIPC–TAZ) in late elderly Japanese patients. This is the first antimicrobial pilot study in late elderly patients with nursing and healthcare associated pneumonia. After PIPC–TAZ administration, PIPC concentrations in plasma were measured chromatographically and the pharmacokinetic parameters were estimated. Efficacy, safety, and bacteriological evaluations were also carried out. The mean age was 85.0 years old and most of the patients were late elderly. Chest X-rays, body temperature, white blood cell count, and C reactive protein all improved significantly, and a high efficacy ratio of 90.9% was observed. Serious nephrotoxicity was observed in 4 cases (18.2%) after administration of PIPC–TAZ. Creatinine clearance (mean±S.D.) measured before PIPC–TAZ therapy was significantly lower in the nephrotoxicity group (32.5±4.4 mL/min) than in the non-nephrotoxicity group (46.1±16.7 mL/min), although the ages were not different between the 2 groups. In the pharmacokinetic parameters for PIPC, total clearance was slightly lower in the nephrotoxicity group than in the non-nephrotoxicity group. However, no significant difference was observed in plasma PIPC levels between the 2 groups. In patients with renal impairment, especially with a creatinine clearance of <40 mL/min, renal impairment was found to be an influencing factor for severe nephrotoxicity following PIPC–TAZ administration. In conclusion, the results suggest that physicians should pay close attention in order to avoid possible toxicity, and that deliberate administration planning and careful follow-up are required in late elderly patients with comprised organ dysfunction.
言語 en
出版者
出版者 The Pharmaceutical Society of Japan
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
関連情報
識別子タイプ DOI
関連識別子 10.1248/bpb.b14-00362
関連情報
識別子タイプ NAID
関連識別子 130004693807
関連情報
識別子タイプ DOI
関連識別子 https://doi.org/10.1248/bpb.b14-00362
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 0918-6158
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1347-5215
収録物識別子
収録物識別子タイプ NCID
収録物識別子 AA10885497
開始ページ
開始ページ 1971
書誌情報 Biological and Pharmaceutical Bulletin
Biological and Pharmaceutical Bulletin

巻 37, 号 12, p. 1971-1976, 発行日 2014-12-01
旧ID 46718
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