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The Pharmacokinetics of Low-Dose Thalidomide in Japanese Patients with Refractory Multiple Myeloma

https://hiroshima.repo.nii.ac.jp/records/2006467
https://hiroshima.repo.nii.ac.jp/records/2006467
62d3576f-0471-44c9-9c27-665123ae01f0
名前 / ファイル ライセンス アクション
BiolPhamBull_29_2331.pdf BiolPhamBull_29_2331.pdf (109.0 KB)
Item type デフォルトアイテムタイプ_(フル)(1)
公開日 2023-03-18
タイトル
タイトル The Pharmacokinetics of Low-Dose Thalidomide in Japanese Patients with Refractory Multiple Myeloma
言語 en
作成者 Kamikawa, Rintaro

× Kamikawa, Rintaro

en Kamikawa, Rintaro

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Ikawa, Kazuro

× Ikawa, Kazuro

en Ikawa, Kazuro

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Morikawa, Norifumi

× Morikawa, Norifumi

en Morikawa, Norifumi

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Asaoku, Hideki

× Asaoku, Hideki

en Asaoku, Hideki

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Iwato, Koji

× Iwato, Koji

en Iwato, Koji

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Sasaki, Ayako

× Sasaki, Ayako

en Sasaki, Ayako

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
権利情報 © 2006 Pharmaceutical Society of Japan
主題
主題Scheme Other
主題 thalidomide
主題
主題Scheme Other
主題 pharmacokinetics
主題
主題Scheme Other
主題 multiple myeloma
主題
主題Scheme NDC
主題 490
内容記述
内容記述 Thalidomide has been used for the treatment of refractory multiple myeloma, the dosage in Japan is lower than in other countries; however, there is little information on the pharmacokinetics and their relationship with the drug response. The aim of this study was to characterize the pharmacokinetics of low-dose thalidomide in Japanese patients with refractory multiple myeloma, and to examine the relationship between pharmacokinetics and adverse events. On the first and second days, a 100 mg capsule was administered to 8 Japanese patients after breakfast and blood samples were obtained. The plasma concentrations were measured using HPLC and analyzed based on a one-compartment model. If intolerable adverse events were not observed for 14 d, the dose was increased to 200 mg. The average apparent volume of distribution (Vd/F), apparent total clearance (CL/F) and area under the plasma concentration–time curve from 0 to infinity (AUC0—∞), which were 45.3 l, 5.5 l/h and 21.7 μg·h/ml, respectively, with smaller Vd/F and CL/F and larger AUC0—∞ than in Caucasian populations. This pharmacokinetic difference may explain the dose difference between Japan and other countries. Adverse events were associated with AUC0—∞, which was best correlated with plasma concentration at 12 h after administration. The 12-h time point was suggested to be a capable indicator for “safety-oriented" therapeutic drug monitoring of thalidomide.
言語 en
出版者
出版者 The Pharmaceutical Society of Japan
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
関連情報
識別子タイプ DOI
関連識別子 10.1248/bpb.29.2331
関連情報
識別子タイプ DOI
関連識別子 https://doi.org/10.1248/bpb.29.2331
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 0918-6158
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1347-5215
収録物識別子
収録物識別子タイプ NCID
収録物識別子 AA10885497
開始ページ
開始ページ 2331
書誌情報 Biological and Pharmaceutical Bulletin
Biological and Pharmaceutical Bulletin

巻 29, 号 11, p. 2331-2334, 発行日 2006-11
旧ID 47053
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