Item type |
デフォルトアイテムタイプ_(フル)(1) |
公開日 |
2023-03-18 |
タイトル |
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タイトル |
The Pharmacokinetics of Low-Dose Thalidomide in Japanese Patients with Refractory Multiple Myeloma |
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言語 |
en |
作成者 |
Kamikawa, Rintaro
Ikawa, Kazuro
Morikawa, Norifumi
Asaoku, Hideki
Iwato, Koji
Sasaki, Ayako
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アクセス権 |
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アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
権利情報 |
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権利情報 |
© 2006 Pharmaceutical Society of Japan |
主題 |
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主題Scheme |
Other |
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主題 |
thalidomide |
主題 |
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主題Scheme |
Other |
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主題 |
pharmacokinetics |
主題 |
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主題Scheme |
Other |
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主題 |
multiple myeloma |
主題 |
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主題Scheme |
NDC |
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主題 |
490 |
内容記述 |
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内容記述 |
Thalidomide has been used for the treatment of refractory multiple myeloma, the dosage in Japan is lower than in other countries; however, there is little information on the pharmacokinetics and their relationship with the drug response. The aim of this study was to characterize the pharmacokinetics of low-dose thalidomide in Japanese patients with refractory multiple myeloma, and to examine the relationship between pharmacokinetics and adverse events. On the first and second days, a 100 mg capsule was administered to 8 Japanese patients after breakfast and blood samples were obtained. The plasma concentrations were measured using HPLC and analyzed based on a one-compartment model. If intolerable adverse events were not observed for 14 d, the dose was increased to 200 mg. The average apparent volume of distribution (Vd/F), apparent total clearance (CL/F) and area under the plasma concentration–time curve from 0 to infinity (AUC0—∞), which were 45.3 l, 5.5 l/h and 21.7 μg·h/ml, respectively, with smaller Vd/F and CL/F and larger AUC0—∞ than in Caucasian populations. This pharmacokinetic difference may explain the dose difference between Japan and other countries. Adverse events were associated with AUC0—∞, which was best correlated with plasma concentration at 12 h after administration. The 12-h time point was suggested to be a capable indicator for “safety-oriented" therapeutic drug monitoring of thalidomide. |
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言語 |
en |
出版者 |
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出版者 |
The Pharmaceutical Society of Japan |
言語 |
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言語 |
eng |
資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
出版タイプ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
関連情報 |
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識別子タイプ |
DOI |
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関連識別子 |
10.1248/bpb.29.2331 |
関連情報 |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1248/bpb.29.2331 |
収録物識別子 |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0918-6158 |
収録物識別子 |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1347-5215 |
収録物識別子 |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA10885497 |
開始ページ |
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開始ページ |
2331 |
書誌情報 |
Biological and Pharmaceutical Bulletin
Biological and Pharmaceutical Bulletin
巻 29,
号 11,
p. 2331-2334,
発行日 2006-11
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旧ID |
47053 |