| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Retention of Multilineage Differentiation Potential of Mesenchymal Cells during Proliferation in Response to FGF |
|
言語 |
en |
| 作成者 |
Tsutsumi, Shinichi
Shimazu, Atsushi
Miyazaki, Kazuko
Pan, Haiou
Koike, Chika
Yoshida, Eri
Takagishi, Kenji
Kato, Yukio
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
権利情報 |
Copyright (c) 2001 Academic Press |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
mesenchymal stem cell |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
FGF |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
multilineage differentiation potential |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
life span |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
|
|
内容記述 |
Mesenchymal stem cells (MSC) that can differentiate to various connective tissue cells may be useful for autologous cell transplantation to defects of bone, cartilage, and tendon, if MSC can be expanded in vitro. However, a short life span of MSC and a reduction in their differentiation potential in culture have limited their clinical application. The purpose of this study is to identify a growth factor(s) involved in self-renewal of MSC and the maintenance of their multilineage differentiation potential. Fibroblast growth factor-2 (FGF-2) markedly increased the growth rate and the life span of rabbit, canine, and human bone marrow MSC in monolayer cultures. This effect of FGF-2 was more prominent in low-density cultures than in high-density cultures. In addition, all MSC expanded in vitro with FGF-2, but not without FGF-2, differentiated to chondrocytes in pellet cultures. The FGF(+) MSC also retained the osteogenic and adipogenic potential throughout many mitotic divisions. These findings suggest that FGFs play a crucial role in self-renewal of MSC. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Elsevier |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
AO |
|
出版タイプResource |
http://purl.org/coar/version/c_b1a7d7d4d402bcce |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1006/bbrc.2001.5777 |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
http://dx.doi.org/10.1006/bbrc.2001.5777 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0006-291X |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00564395 |
| 開始ページ |
|
|
開始ページ |
413 |
| 書誌情報 |
Biochemical and Biophysical Research Communications
Biochemical and Biophysical Research Communications
巻 288,
号 2,
p. 413-419,
発行日 2001-10-26
|
| 旧ID |
21548 |
BBRC_288_413.pdf (1.1 MB)
