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Muscle vasodilator response via potential adrenaline secretion to L-cysteine microinjected in rostral ventrolateral medulla of rats
https://hiroshima.repo.nii.ac.jp/records/2006357
https://hiroshima.repo.nii.ac.jp/records/200635735b9c9a8-6420-4941-91cc-ff0e83bf74d9
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AutonomicNeuroscience_224_102644.pdf (922.4 KB)
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| Item type | デフォルトアイテムタイプ_（フル）(1) | |||||||
|---|---|---|---|---|---|---|---|---|
| 公開日 | 2023-03-18 | |||||||
| タイトル | ||||||||
| タイトル | Muscle vasodilator response via potential adrenaline secretion to L-cysteine microinjected in rostral ventrolateral medulla of rats | |||||||
| 言語 | en | |||||||
| 作成者 |
Takemoto, Yumi
× Takemoto, Yumi
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| アクセス権 | ||||||||
| アクセス権 | open access | |||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
| 権利情報 | ||||||||
| 権利情報 | © 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||||
| 権利情報 | ||||||||
| 権利情報 | This is not the published version. Please cite only the published version. この論文は出版社版ではありません。引用の際には出版社版をご確認、ご利用ください。 | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | L-Cysteine | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Ionotropic excitatory amino acid receptors | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | RVLM | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Muscle vasodilation | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Adrenaline secretion | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Rats | |||||||
| 内容記述 | ||||||||
| 内容記述 | We previously found that the thiol amino acid L-cysteine microinjected into rat medullary autonomic areas produces changes in arterial blood pressure (AP) via ionotropic excitatory amino acid receptors (iEAAr), but its effect on vascular beds is still unknown. Rostral ventrolateral medulla (RVLM) pressor area includes adrenal and lumbar presympathetic neurons which activation could cause opposite muscle vascular responses: vasodilation versus vasoconstriction. However, there are few data on the vasodilator response in rats. Ionotropic EAAr activation alone with L-cysteine may be effective to differentiate RVLM sites for those opposite responses. To test it, muscle blood flow responses to L-cysteine were mapped in the ventrolateral medulla (VLM) of rats. In anesthetized rats with a cranial window above the VLM, hindquarter flow (HQF) and AP were monitored, providing hindquarter resistance (HQR) by dividing AP by HQF. L-Cysteine mapping in VLM including caudal depressor vasodilator area defined with L-glutamate showed HQR responses in parallel to AP responses, suggesting the importance of iEAAr in muscle vascular regulation. Microinjections of L-cysteine into RVLM succeeded to detect sites of slower muscle vasodilation and blockade of peripheral β-adrenoceptors abolished this response, indicating potential adrenaline secretion. Although there was no functional topography, the iEAAr activation alone with L-cysteine can differentiate sites of muscle vasodilation from vasoconstriction in rat RVLM. The neuromodulator candidate L-cysteine is a useful tool when chemical stimulation of iEAAr is required. | |||||||
| 言語 | en | |||||||
| 内容記述 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | This work was supported by Japan Society for the Promotion of Science (JSPS), Grant-in-Aid for Scientific Research (Kakenhi) grant number JP18K06854. | |||||||
| 出版者 | ||||||||
| 出版者 | Elsevier | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | journal article | |||||||
| 出版タイプ | ||||||||
| 出版タイプ | AO | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_b1a7d7d4d402bcce | |||||||
| 関連情報 | ||||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | 10.1016/j.autneu.2020.102644 | |||||||
| 関連情報 | ||||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | https://doi.org/10.1016/j.autneu.2020.102644 | |||||||
| 収録物識別子 | ||||||||
| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 1566-0702 | |||||||
| 開始ページ | ||||||||
| 開始ページ | 102644 | |||||||
| 書誌情報 |
Autonomic Neuroscience Autonomic Neuroscience 巻 224, p. 102644, 発行日 2020-03 |
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| 旧ID | 50432 | |||||||
| 備考 | Post-print version/PDF may be used in an institutional repository after an embargo period of 12 months. | |||||||
