| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Oral infection-inflammatory pathway, periodontitis, is a risk factor for endothelial dysfunction in patients with coronary artery disease |
|
言語 |
en |
| 作成者 |
Higashi, Yukihito
Goto, Chikara
Hidaka, Takayuki
Soga, Junko
Nakamura, Shuji
Fujii, Yuichi
Hata, Takaki
Idei, Naomi
Fujimura, Noritaka
Chayama, Kazuaki
Kihara, Yasuki
Taguchi, Akira
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
権利情報 |
Copyright (c) 2009 Elsevier Ireland Ltd. |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Periodontitis |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Coronary artery disease |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Endothelial function |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Inflammation |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
|
|
内容記述 |
Objective: Several studies have shown that periodontitis is a risk factor for cardiovascular diseases. There is an association between inflammation and endothelial dysfunction. The purpose of this study was to evaluate endothelial function in patients with coronary artery disease (CAD) who had periodontitis. Methods and results: We evaluated forearm blood flow (FBF) responses to acetylcholine (ACh), an endothelium-dependent vasodilator, and to sodium nitroprusside (SNP), an endothelium-independent vasodilator, in 101 CAD patients with periodontitis (37 men and 11 women, 63 +/- 12 yr) and without periodontitis (36 men and 17 women, 62 +/- 13 yr). FBF was measured by using strain-gauge plethysmography. Circulating levels of C-reactive protein and interleukin-6 were significantly higher in the periodontitis group than in the non-periodontitis group. FBF response to ACh was significantly smaller in the periodontitis group than in the non-periodontitis group. SNP-stimulated vasodilation was similar in the two groups. Periodontal therapy reduced serum concentrations of C-reactive protein from 2.7 +/- 1.9 to 1.8 +/- 0.9 mg/L (P < 0.05) and interleukin-6 from 2.6 +/- 3.4 to 1.6 +/- 2.6 ng/L (P < 0.05) and augmented ACh-induced vasodilation from 14.7 +/- 5.2 to 20.1 +/- 6.1 mL/(min 100 mL) tissue (P < 0.05) in patients with periodontitis. The SNP-stimulated vasodilation was similar before and after treatment. After administration of NG-monomethyl-l-arginine, a nitric oxide synthase inhibitor, FBF response to ACh was similar before and after treatment. Conclusion: These findings suggest that periodontitis is associated with endothelial dysfunction in patients with CAD through a decrease in nitric oxide bioavailability. Systemic inflammation may be, at least in part, a cause and predictor of progression of endothelial dysfunction. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Elsevier Ireland Ltd |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
AO |
|
出版タイプResource |
http://purl.org/coar/version/c_b1a7d7d4d402bcce |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1016/j.atherosclerosis.2009.03.037 |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
http://dx.doi.org/10.1016/j.atherosclerosis.2009.03.037 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0021-9150 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00553457 |
| 開始ページ |
|
|
開始ページ |
604 |
| 書誌情報 |
Atheroscierosis
Atheroscierosis
巻 206,
号 2,
p. 604-610,
発行日 2009-10
|
| 旧ID |
28862 |
Atheroscierosis_206_604.pdf (179.8 KB)
