| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Injury and repair of the soleus muscle after electrical stimulation of the sciatic nerve in the rat |
|
言語 |
en |
| 作成者 |
Matsuura, Natsue
Kawamata, Seiichi
Ozawa, Junya
Kai, Satoru
Sakakima, Harutoshi
Abiko, Sachiko
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
|
|
内容記述 |
To study injury and subsequent changes in skeletal muscles, the rat sciatic nerve was electrically stimulated at 50 Hz and muscle contraction was induced for 30 min. Muscle damage was classified into five types (hypercontraction, hyperstretching, Z band disorders, misalignment of myofilament and regions of scarce myofilaments) by electron microscopy and quantified by ultrastructural assessment. After electrical nerve stimulation, the percentages of the injured areas of the soleus muscle were 18.8 ± 15.8% (mean ± SD) at O h, 9.7 ± 1.0 0x1.3f1c4p-890t 6 h, 22.0 ± 23.6 0x0p+0t 12 h, 13.1 ± 3.2 0x0p+0t 24 h, 4.9 ± 6.0 0x0p+0t 3 days and 0.5 ± 0.4 0x0p+0t 7 days. At 0 h, the vast majority of ultrastructural alterations were sarcomere hypercontraction. At 6 h, hypercontraction was not recognizable and sarcomere hyperstretching and Z band disarrangement constituted the major findings. At 12 h, when the injury reaehed its maximum, myofilament disorganization and hyperstretching were predominant. At 24 h or afterwards, the injury began to decrease and recovered to almost normal conditions by 7 days. There were very few necrotic muscle fibers in all specimens. It is considered that the muscle lesions in the present study were reversible, and recovered through changes in various types of sarcomere alterations. Z band streaming and free ribosomes were frequently found at 12 and 24 h, which may indicate repair processes rather than newly formed lesions. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
International Society of Histology and Cytology |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1679/aohc.64.393 |
| 関連情報 |
|
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
11757908 |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
http://dx.doi.org/10.1679/aohc.64.393 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA1068990X |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0914-9465 |
| 開始ページ |
|
|
開始ページ |
393 |
| 書誌情報 |
Archives of Histology and Cytology
Archives of Histology and Cytology
巻 64,
号 4,
p. 393-400,
発行日 2001
|
| 旧ID |
20793 |
AOHC_64_393.pdf (1.1 MB)
