| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Protective Effects of Japanese Soybean Paste (Miso) on Stroke in Stroke-Prone Spontaneously Hypertensive Rats (SHRSP) |
|
言語 |
en |
| 作成者 |
Watanabe, Hiromitsu
Sasatani, Megumi
Doi, Toshiki
Masaki, Takao
Satoh, Kenichi
Yoshizumi, Masao
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
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|
権利情報 |
Copyright © 2017 American Journal of Hypertension, Ltd. |
| 権利情報 |
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|
権利情報 |
This document is the Accepted Manuscript version of a Published Work that appeared in final form in 'American Journal of Hypertension', copyright c American Journal of Hypertension after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1093/ajh/hpx129. |
| 権利情報 |
|
|
権利情報 |
This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
| 主題 |
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|
主題Scheme |
Other |
|
主題 |
blood pressure |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
brain protection |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
hypertension, miso (Japanese soy bean paste) |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
SHRSP |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
stroke |
| 内容記述 |
|
|
内容記述 |
[BACKGROUND AND HYPOTHESIS] Soybean isoflavones have been shown to reduce the risk of cerebral infarction in humans according to epidemiological studies. However, whether intake of miso can reduce the incidence of stroke in animal models remains unknown. In this study, we investigated the effects of soybean paste (miso) in an animal model of stroke. [METHODS] Stroke-prone spontaneously hypertensive rats (SHRSP) were fed a miso diet (normal diet 90%, miso 10%; final NaCl content 2.8%), a high salt diet (normal diet and NaCl 2.5%; final NaCl content 2.8%), or a low salt diet (normal diet; final NaCl content 0.3%). [RESULTS] Kaplan–Meier survival curves revealed a significantly lower survival rate in the high salt group compared to the miso group (P = 0.002) and the low salt group (P ≤ 0.001). Large hemorrhagic macules were found in the cerebrum in the high salt group, whereas none were found in the other 2 groups. There were also fewer histological and immunohistochemical changes in the brain and kidneys in the miso group compared to the high salt group. [CONCLUSION] Our results suggest that miso may have protective effects against stroke despite its high salt content. |
|
言語 |
en |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
This work was supported by a grant-in-aid from the Central Miso Institute, Tokyo, Japan |
| 出版者 |
|
|
出版者 |
Oxford University Press |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
AO |
|
出版タイプResource |
http://purl.org/coar/version/c_b1a7d7d4d402bcce |
| 関連情報 |
|
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1093/ajh/hpx129 |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1093/ajh/hpx129 |
| 関連情報 |
|
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
28985324 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1941-7225 |
| 開始ページ |
|
|
開始ページ |
43 |
| 書誌情報 |
American Journal of Hypertension
American Journal of Hypertension
巻 31,
号 1,
p. 43-47,
発行日 2017-07-31
|
| 旧ID |
48138 |
| 備考 |
Post-print version/PDF may be used in an institutional repository after an embargo period of 12 months. |
Ajh_31_43.pdf (750.8 KB)
