| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Flow cytometry-based diagnosis of primary immunodeficiency diseases |
|
言語 |
en |
| 作成者 |
Kanegane, Hirokazu
Hoshino, Akihiro
Okano, Tsubasa
Yasumi, Takahiro
Wada, Taizo
Takada, Hidotoshi
Okada, Satoshi
Yamashita, Motoi
Yeh, Tzu-wen
Nishikomori, Ryuta
Takagi, Masatoshi
Imai, Kohsuke
Ochs, Hans D.
Morio, Tomohiro
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
権利情報 |
Copyright © 2017, Japanese Society of Allergology. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Flow cytometry |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Intracellular protein |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Monoclonal antibody |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Primary immunodeficiency disease |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Surface protein |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
|
|
内容記述 |
Primary immunodeficiencies (PIDs) are a heterogeneous group of inherited diseases of the immune system. The definite diagnosis of PID is ascertained by genetic analysis; however, this takes time and is costly. Flow cytometry provides a rapid and highly sensitive tool for diagnosis of PIDs. Flow cytometry can evaluate specific cell populations and subpopulations, cell surface, intracellular and intranuclear proteins, biologic effects associated with specific immune defects, and certain functional immune characteristics, each being useful for the diagnosis and evaluation of PIDs. Flow cytometry effectively identifies major forms of PIDs, including severe combined immunodeficiency, X-linked agammaglobulinemia, hyper IgM syndromes, Wiskott-Aldrich syndrome, X-linked lymphoproliferative syndrome, familial hemophagocytic lymphohistiocytosis, autoimmune lymphoproliferative syndrome, IPEX syndrome, CTLA 4 haploinsufficiency and LRBA deficiency, IRAK4 and MyD88 deficiencies, Mendelian susceptibility to mycobacterial disease, chronic mucocuneous candidiasis, and chronic granulomatous disease. While genetic analysis is the definitive approach to establish specific diagnoses of PIDs, flow cytometry provides a tool to effectively evaluate patients with PIDs at relatively low cost. |
|
言語 |
en |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
This study was supported by grants from the Ministry of Education, Culture, Sports, Science, and Technology of Japan and the Ministry of Health, Labour, and Welfare of Japan. |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Supplementary data related to this article can be found at http://dx.doi.org/10.1016/j.alit.2017.06.003 |
| 出版者 |
|
|
出版者 |
Japanese Society of Allergology |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1016/j.alit.2017.06.003 |
| 関連情報 |
|
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
28684198 |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1016/j.alit.2017.06.003 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1323-8930 |
| 開始ページ |
|
|
開始ページ |
43 |
| 書誌情報 |
Allergology International
Allergology International
巻 67,
号 1,
p. 43-54,
発行日 2018-01
|
| 旧ID |
47026 |
AI_67_43.pdf (1.2 MB)
