| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Photodynamic Activities of Porphyrin Derivative–Cyclodextrin Complexes by Photoirradiation |
|
言語 |
en |
| 作成者 |
Ikeda, Atsushi
Satake, Shuhei
Mae, Tomoya
Ueda, Masafumi
Sugikawa, Kouta
Shigeto, Hajime
Funabashi, Hisakage
Kuroda, Akio
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
権利情報 |
Copyright (c) 2017 American Chemical Society |
| 権利情報 |
|
|
権利情報 |
This document is the Accepted Manuscript version of a Published Work that appeared in final form in 'ACS Medicinal Chemistry Letters', copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acsmedchemlett.7b00098. |
| 権利情報 |
|
|
権利情報 |
This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
porphyrin |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
cyclodextrin |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
photodynamic therapy |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
photosensitizer |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
430 |
| 内容記述 |
|
|
内容記述 |
Water-soluble cyclodextrin (CyD)-complexed with porphyrin derivatives with different substituents in the mesopositions showed different photodynamic activities toward cancer cells under illumination at wavelengths over 600 nm, the most suitable wavelengths for photodynamic therapy (PDT). In particular, aniline- and phenol-substituted derivatives had high photodynamic activity because of the efficient intracellular uptake of the complexes by tumor cells. These complexes showed greater photodynamic activity than photofrin, currently the main drug in clinical use as a photosensitizer. These results represent a significant step towards the optimization of porphyrin derivatives as photosensitizers. |
|
言語 |
en |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Supporting Information is available free of charge on the ACS Publications website. Experimental procedures and UV-vis absorption and NMR spectra (PDF). |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
This work was supported by JSPS KAKENHI Grant-in-Aid for Scientific Research (B) (Grant No. JP16H04133) and Grant-in-Aid for Challenging Exploratory Research (Grant No. JP16K13982) and the Electric Technology Research Foundation of Chugoku. |
| 出版者 |
|
|
出版者 |
American Chemical Society |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
AO |
|
出版タイプResource |
http://purl.org/coar/version/c_b1a7d7d4d402bcce |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1021/acsmedchemlett.7b00098 |
| 関連情報 |
|
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
28523110 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1948-5875 |
| 開始ページ |
|
|
開始ページ |
555 |
| 書誌情報 |
ACS Medicinal Chemistry Letters
ACS Medicinal Chemistry Letters
巻 8,
号 5,
p. 555-559,
発行日 2017-05-11
|
| 旧ID |
46209 |
ACSMedCL_8-5_555.pdf (609.0 KB)
