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アイテム
インターロイキン1αは線維芽細胞依存的にマスト細胞の増殖を促進する
https://hiroshima.repo.nii.ac.jp/records/2005345
https://hiroshima.repo.nii.ac.jp/records/2005345822d392b-1a17-43dc-8f64-982b4bb7ec7a
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
diss_otsu3383.pdf (364.6 KB)
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| Item type | デフォルトアイテムタイプ_（フル）(1) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2023-03-18 | |||||||||
| タイトル | ||||||||||
| タイトル | Interleukin-1α enhances mast cell growth by a fibroblast-dependent mechanism | |||||||||
| 言語 | en | |||||||||
| タイトル | ||||||||||
| タイトル | インターロイキン1αは線維芽細胞依存的にマスト細胞の増殖を促進する | |||||||||
| 言語 | ja | |||||||||
| 作成者 |
亀好, 良一
× 亀好, 良一
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| アクセス権 | ||||||||||
| アクセス権 | open access | |||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||
| 権利情報 | ||||||||||
| 権利情報 | Copyright (c) 2000 by Author | |||||||||
| 主題 | ||||||||||
| 主題Scheme | NDC | |||||||||
| 主題 | 490 | |||||||||
| 内容記述 | ||||||||||
| 内容記述 | Mast cell hyperplasia is observed in variousinflammatory skin diseases. Although the pathogenesis of these conditions remains largely uninvestigated, it is speculated that lesional mediators provide favorable microenvironment for mast cell growth. We have investigated the effect of an inflammatory cytokine, IL-1, on mast cell growth in a mast cell/fibroblast co-culture system. When mouse bone marrow-derived cultured mast cells (BMMC) were cultured on a NIH/3T3 fibroblast monolayer, IL-1 stimulated mast cell proliferation. However, IL-1did not stimulate 3H-thymidine incorporation in BMMC in the absence of fibroblasts. Separation of BMMC from fibroblasts by a permeable micropore membrane reduced the effect of IL-1. When BMMC were prepared from W/Wv-mice, which lack functional c-kit, or when NIH/3T3 fibroblasts were substituted with Sl/Sld-derived fibroblasts, which lack membrane-bound stem cell factor (SCF), a lower, but significant, effect of IL-1 was observed. Flow cytometric analysis revealed no enhancement of SCF expression on fibroblasts by IL-1. Neutralizing antibodies against IL-3, IL-4, IL-10, and nerve growth factor (NGF) showed no inhibition. On the other hand, indomethacin inhibited the effect of IL-1, and prostaglandin E2 induced mast cell growth in the co-culture. These results indicate that IL-1 stimulates mast cell growth by a fibroblast-dependent mechanism, where SCF/c-kit interaction may participate in a major way. The mast cell growth activity induced by this cytokine is, at least in part, attributed to prostaglandins. Inflammatory cytokines may thus contribute to mast cell hyperplasia in skin diseases. | |||||||||
| 言語 | en | |||||||||
| 出版者 | ||||||||||
| 出版者 | Hiroshima University | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||||
| 資源タイプ | doctoral thesis | |||||||||
| 学位授与番号 | ||||||||||
| 学位授与番号 | 乙第3383号 | |||||||||
| 学位名 | ||||||||||
| 言語 | ja | |||||||||
| 学位名 | 博士(医学) | |||||||||
| 学位名 | ||||||||||
| 言語 | en | |||||||||
| 学位名 | Medicine | |||||||||
| 学位授与年月日 | ||||||||||
| 学位授与年月日 | 2000-06-22 | |||||||||
| 学位授与機関 | ||||||||||
| 学位授与機関識別子Scheme | kakenhi | |||||||||
| 学位授与機関識別子 | 15401 | |||||||||
| 言語 | ja | |||||||||
| 学位授与機関名 | 広島大学 | |||||||||
| 学位授与機関 | ||||||||||
| 言語 | en | |||||||||
| 学位授与機関名 | Hiroshima University | |||||||||
| 旧ID | 14282 | |||||||||
