WEKO3
アイテム
スキルス胃癌の間質の線維芽細胞においてMicroRNA-143はcollagen type IIIの発現を制御する
https://hiroshima.repo.nii.ac.jp/records/2005185
https://hiroshima.repo.nii.ac.jp/records/2005185f8486b66-2eb4-4f09-9bca-b24db4e8c612
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
k6383_3.pdf (1.7 MB)
|
||
|
k6383_1.pdf (275.5 KB)
|
||
|
k6383_2.pdf (174.1 KB)
|
| Item type | デフォルトアイテムタイプ_（フル）(1) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2014-11-21 | |||||||||
| タイトル | ||||||||||
| タイトル | MicroRNA-143 regulates collagen type III expression in stromal fibroblasts of scirrhous type gastric cancer. | |||||||||
| 言語 | en | |||||||||
| タイトル | ||||||||||
| タイトル | スキルス胃癌の間質の線維芽細胞においてMicroRNA-143はcollagen type IIIの発現を制御する | |||||||||
| 言語 | ja | |||||||||
| 作成者 |
内藤, 寛
× 内藤, 寛
|
|||||||||
| アクセス権 | ||||||||||
| アクセス権 | open access | |||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||
| 権利情報 | ||||||||||
| 権利情報 | Copyright(c) by Author | |||||||||
| 主題 | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Collagen type III | |||||||||
| 主題 | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | fibroblast | |||||||||
| 主題 | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | gastric cancer | |||||||||
| 主題 | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | microRNA-143 | |||||||||
| 主題 | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | transforming growth factor-β | |||||||||
| 主題 | ||||||||||
| 主題Scheme | NDC | |||||||||
| 主題 | 490 | |||||||||
| 内容記述 | ||||||||||
| 内容記述 | Gastric cancer (GC) is one of the most common malignancies worldwide. In particular, scirrhous type GC is highly metastatic and is characterized clinically by rapid disease progression and poor prognosis. MicroRNAs (miRNAs) play crucial roles in cancer development and progression. In the present study, we identified several miRNAs that are expressed at higher levels in scirrhous type GC than in non-scirrhous type GC by miRNA microarray analysis. Among these, microRNA-143 (miR- 143) expression was higher in scirrhous type GC than in non-scirrhous types of GC. In situ hybridization and quantitative RT-PCR analysis showed that miR-143 is expressed by stromal fibroblasts but not by cancer cells. In stromal cells, miR-143 enhanced collagen type III expression in normal gastric fibroblasts and cancerassociated fibroblasts through activation of transforming growth factor-β) /SMAD signaling. Furthermore, high miR-143 expression in GC was associated with worse cancer-specific mortality (P = 0.0141). Multivariate analysis revealed that miR-143 was an independent prognostic factor. Treatment of GC cell lines with 5-aza-2'- deoxycytidine restored the expression of miR-143, and precursor miR-143 caused the inhibition of cancer cell invasion. These data suggest that miR-143 regulates fibrosis of scirrhous type GC through induction of collagen expression in stromal fibroblasts and that miR-143 expression serves as a prognostic marker of GC. | |||||||||
| 言語 | en | |||||||||
| 日付 | ||||||||||
| 日付 | 2014-11-21 | |||||||||
| 日付タイプ | Created | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||||
| 資源タイプ | doctoral thesis | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | NA | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_be7fb7dd8ff6fe43 | |||||||||
| 関連情報 | ||||||||||
| 関連タイプ | references | |||||||||
| 関連名称 | Yutaka Naito, Naoya Sakamoto, Naohide Oue, Masakazu Yashiro, Kazuhiro Sentani, Kazuyoshi Yanagihara, Kosei Hirakawa and Wataru Yasui; MicroRNA-143 regulates collagen type III expression in stromal fibroblasts of scirrhous type gastric cancer; Cancer Science Volume 105, Issue 2, pages 228-235, February 2014 (DOI: 10.1111/cas.12329) | |||||||||
| 関連情報 | ||||||||||
| 関連タイプ | references | |||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | http://dx.doi.org/10.1111/cas.12329 | |||||||||
| 学位授与番号 | ||||||||||
| 学位授与番号 | 甲第6383号 | |||||||||
| 学位名 | ||||||||||
| 言語 | ja | |||||||||
| 学位名 | 博士(医学) | |||||||||
| 学位名 | ||||||||||
| 言語 | en | |||||||||
| 学位名 | Philosophy in Medical Science | |||||||||
| 学位授与年月日 | ||||||||||
| 学位授与年月日 | 2014-03-23 | |||||||||
| 学位授与機関 | ||||||||||
| 学位授与機関識別子Scheme | kakenhi | |||||||||
| 学位授与機関識別子 | 15401 | |||||||||
| 言語 | ja | |||||||||
| 学位授与機関名 | 広島大学 | |||||||||
| 学位授与機関 | ||||||||||
| 言語 | en | |||||||||
| 学位授与機関名 | Hiroshima University | |||||||||
| 旧ID | 36302 | |||||||||
