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寛解期双極性障害患者の心理社会的機能は言語流暢性課題遂行中の前帯状回および左外側頭野の賦活と関連する : 機能的MRIを用いた予備的研究
https://hiroshima.repo.nii.ac.jp/records/2005069
https://hiroshima.repo.nii.ac.jp/records/20050691df66ee9-fbd4-4462-9c7b-a2b1cf943236
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o4218_3.pdf (442.2 KB)
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o4218_1.pdf (166.9 KB)
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o4218_2.pdf (186.1 KB)
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| Item type | デフォルトアイテムタイプ_（フル）(1) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2023-03-18 | |||||||||
| タイトル | ||||||||||
| タイトル | Psychosocial functioning is correlated with activation in the anterior cingulate cortex and left lateral prefrontal cortex during a verbal fluency task in euthymic bipolar disorder : a preliminary fMRI study | |||||||||
| 言語 | en | |||||||||
| タイトル | ||||||||||
| タイトル | 寛解期双極性障害患者の心理社会的機能は言語流暢性課題遂行中の前帯状回および左外側頭野の賦活と関連する : 機能的MRIを用いた予備的研究 | |||||||||
| 言語 | ja | |||||||||
| 作成者 |
吉村, 靖司
× 吉村, 靖司
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| アクセス権 | ||||||||||
| アクセス権 | open access | |||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||
| 主題 | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | bipolar disorder | |||||||||
| 主題 | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | euthymia | |||||||||
| 主題 | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | functional magnetic resonance imaging | |||||||||
| 主題 | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | prefrontal cortex | |||||||||
| 主題 | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | psychosocial functioning | |||||||||
| 主題 | ||||||||||
| 主題Scheme | NDC | |||||||||
| 主題 | 490 | |||||||||
| 内容記述 | ||||||||||
| 内容記述 | Aim: Cognitive impairment may account for functional and occupational disability in patients with bipolar disorder even during periods of euthymia. While imaging suggests structural, neurochemical, and functional abnormalities in bipolar disorder patients, the pathophysiology of these deficits has not been elucidated. It was hypothesized that euthymic bipolar patients would have different cortical activation during a verbal fluency task compared to healthy controls, and that psychosocial functioning would be associated with prefrontal cortical activation during the task in the bipolar group. Methods: Ten euthymic bipolar patients and 10 healthy control participants (matched for age, gender, and years of education) underwent functional magnetic resonance imaging (fMRI) during a verbal fluency task, tapping task and visual task. Correlational analysis between the fMRI brain activation and clinical variables of the participants, including Global Assessment of Functioning (GAF) score, was performed. Results: Compared to the controls, euthymic bipolar patients had significantly greater activation in the bilateral precuneus with similar behavioral performance during the verbal fluency task. There were no significant differences between the groups for the visual task or the simple motor task. Activation in both the left anterior cingulate cortex (ACC) and the left dorsolateral prefrontal cortex (PFC) were significantly positively correlated with GAF score in the euthymic bipolar patients. Conclusion: Both the ACC and lateral PFC regions are components of a neural network that plays a critical role in psychosocial functioning, and are often found to be affected in bipolar patients. | |||||||||
| 言語 | en | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||||
| 資源タイプ | doctoral thesis | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | NA | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_be7fb7dd8ff6fe43 | |||||||||
| 関連情報 | ||||||||||
| 関連タイプ | references | |||||||||
| 関連名称 | Yasushi Yoshimura, Yasumasa Okamoto, Keiichi Onoda, Go Okada, Shigeru Toki, Atsuo Yoshino, Hidehisa Yamashita, and Shigeto Yamawaki; Psychosocial functioning is correlated with activation in the anterior cingulate cortex and left lateral prefrontal cortex during a verbal fluency task in euthymic bipolar disorder: A preliminary fMRI study; Psychiatry and Clinical Neurosciences, Volume 68, Issue 3, pages 188-196, March 2014 (doi: 10.1111/pcn.12115) | |||||||||
| 関連情報 | ||||||||||
| 関連タイプ | references | |||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | http://doi.org/10.1111/pcn.12115 | |||||||||
| 学位授与番号 | ||||||||||
| 学位授与番号 | 乙第4218号 | |||||||||
| 学位名 | ||||||||||
| 言語 | ja | |||||||||
| 学位名 | 博士(医学) | |||||||||
| 学位名 | ||||||||||
| 言語 | en | |||||||||
| 学位名 | Philosophy in Medical Science | |||||||||
| 学位授与年月日 | ||||||||||
| 学位授与年月日 | 2014-01-23 | |||||||||
| 学位授与機関 | ||||||||||
| 学位授与機関識別子Scheme | kakenhi | |||||||||
| 学位授与機関識別子 | 15401 | |||||||||
| 言語 | ja | |||||||||
| 学位授与機関名 | 広島大学 | |||||||||
| 学位授与機関 | ||||||||||
| 言語 | en | |||||||||
| 学位授与機関名 | Hiroshima University | |||||||||
| 旧ID | 40609 | |||||||||
