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TMJ tissue engineering : From the disc to condyle
https://hiroshima.repo.nii.ac.jp/records/2000962
https://hiroshima.repo.nii.ac.jp/records/200096224e00110-b871-4b88-ab99-29acd890bb79
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
47-49.pdf (2.5 MB)
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| Item type | デフォルトアイテムタイプ_（フル）(1) | |||||||
|---|---|---|---|---|---|---|---|---|
| 公開日 | 2023-03-18 | |||||||
| タイトル | ||||||||
| タイトル | TMJ tissue engineering : From the disc to condyle | |||||||
| 言語 | en | |||||||
| 作成者 |
Detamore, Michael S.
× Detamore, Michael S.
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| アクセス権 | ||||||||
| アクセス権 | open access | |||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | temporomandibular joint | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | TMJ | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | tissue engineering | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | TMJ disc | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | TMJ condyle | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | cartilage tissue engineering | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | HUCM stem cell | |||||||
| 主題 | ||||||||
| 主題Scheme | NDC | |||||||
| 主題 | 490 | |||||||
| 内容記述 | ||||||||
| 内容記述 | The field of TMJ tissue engineering is blossoming, a field that was onnce far behind orthopaedic tissue engineering is rapidly gaining ground. Both TMJ disc and TMJ condyle tissue engineering efforts present unique challenges and will ultimiately be necessary to regenerate TMJs for patients suffering form severe disorders. The TMJ disc is a fibrocartilaginous structure with complex attachments, where tensile mechanical integrity is a crucial design requirement. The TMJ condyle presents the challenge of engineering both bone and cartilage. Its cartilage is a fibrocartilage with four distinct zones, and the design requirement for mechanical integrity is the ability to resist compression and shear. We are focusing our efforts in all three areas of the tissue engineering triad: cell source, scaffold selection, and chemical signals. With regard to cell source, we are interested in comparing a traditional source of cartilage cells with an exciting new source in human umbilical cord matrix(HUCM) stem cells for engineering cartilage. The HUCM stem cells have shown promise in their ability to synthesize GAGs and collagen on poly(glycolic acid) scaffolds. Moreover, we have initial data to suggest that HUCM stem cells will be strong candidates for bone tissue engineering as well. Regarding scaffold selection, we are currently investigating new hydrogels and novel approaches to designing poly(lactic-co-glycolic acid) scaffolds. Our research in chemical signals has focused on the use of glucosamine, and on the use of proteglycans along with growth factors. Our results have suggested that glucosamine may have a beneficial effect on TMJ condylar cartilage cells in culture, and effective concentration ranges are currently being investigated. | |||||||
| 言語 | en | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_5794 | |||||||
| 資源タイプ | conference paper | |||||||
| 出版タイプ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
| 関連情報 | ||||||||
| 関連タイプ | isPartOf | |||||||
| 識別子タイプ | URI | |||||||
| 関連識別子 | http://ir.lib.hiroshima-u.ac.jp/00014841 | |||||||
| 開始ページ | ||||||||
| 開始ページ | 47 | |||||||
| 書誌情報 |
International Conference on TMJ Replacement and Tissue Engineering in Hiroshima : 顎関節部の再建と組織再生に関する国際カンファレンス-広島 International Conference on TMJ Replacement and Tissue Engineering in Hiroshima : 顎関節部の再建と組織再生に関する国際カンファレンス-広島 p. 47-56, 発行日 2006-03 |
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| 旧ID | 14363 | |||||||
