| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Mechanisms of temporomandibular joint-osteoarthrosis (TMJ-OA) : Biomechanical, histological and biochemical evidences |
|
言語 |
en |
| 作成者 |
Tanne, Kazuo
Honda, Kobun
Sugiyama, H
Ohno, S
Tanaka, Eiji
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
temporomandibular joint disorder |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
osteoarthrosis |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
condylar resorption |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
mechanical stress |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
orthodontic treatment |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
|
|
内容記述 |
Condylar resorption in the TMJ or TMJ-OA has been experienced occasionally in daily orthodontic practice and recognized to induce substantial influences on craniofacial morphology and the treatment outcomes. This study was designed to investigate the mechanisms of TMJ-OA by means of biomechanical, histological and biochemical approaches. Biomechanical study with finite element stress analysis revealed an existence of large compressive stresses in the anterior, middle and lateral areas on the condyle and prominent increases in the compressive stresses in association with vertical discrepancy of the craniofacial skeleton. Such skeletal discrepancy, simulated in growing rats by placing a metal plate on the upper molars, produced a decrease in the thickness of cartilage layers and an increase in the number of TRAP-positive cells, both of which lead to degenerative changes in the articular cartilage of the mandibular condyle. Furthermore, excessive tensile stresses, applied to articular chondrocytes with use of the Flexercell Strain Unit, induced an imbalance between matrix metalloproteinases(MMPs) and tissue inhibitors of matrix metalloproteinases(TIMPs), which is assumed to induce lower resistance to external stimuli and degenerative changes leading to the resorption of bone and cartilage. It is thus shown that excessive or imbalanced mechanical loading on the TMJ components from occlusal and skeletal discrepancies induce various degenerative responses of cartilaginous tissues and articular chondrocytes, leading to the destruction of bone or cartilage in TMJ-OA. |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_5794 |
|
資源タイプ |
conference paper |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連情報 |
|
|
関連タイプ |
isPartOf |
|
|
識別子タイプ |
URI |
|
|
関連識別子 |
http://ir.lib.hiroshima-u.ac.jp/00014841 |
| 開始ページ |
|
|
開始ページ |
23 |
| 書誌情報 |
International Conference on TMJ Replacement and Tissue Engineering in Hiroshima : 顎関節部の再建と組織再生に関する国際カンファレンス-広島
International Conference on TMJ Replacement and Tissue Engineering in Hiroshima : 顎関節部の再建と組織再生に関する国際カンファレンス-広島
p. 23-29,
発行日 2006-03
|
| 旧ID |
14301 |
23-29.pdf (7.2 MB)
