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Skeletal development through the regulation of chondrocyte and osteoblast differentiation by Runx2
https://hiroshima.repo.nii.ac.jp/records/2000950
https://hiroshima.repo.nii.ac.jp/records/2000950ced87af5-6955-4c98-a3f5-ed1b6ab9ebca
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Symp-Edu-Sci_133-136.pdf (658.9 KB)
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| Item type | デフォルトアイテムタイプ_（フル）(1) | |||||||
|---|---|---|---|---|---|---|---|---|
| 公開日 | 2023-03-18 | |||||||
| タイトル | ||||||||
| タイトル | Skeletal development through the regulation of chondrocyte and osteoblast differentiation by Runx2 | |||||||
| 言語 | en | |||||||
| 作成者 |
Komori, Toshihisa
× Komori, Toshihisa
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| アクセス権 | ||||||||
| アクセス権 | open access | |||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Runx2 | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | chondrocyte differentiation | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | osteoblast differentiation | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Runx3 | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Cbfb | |||||||
| 主題 | ||||||||
| 主題Scheme | NDC | |||||||
| 主題 | 490 | |||||||
| 内容記述 | ||||||||
| 内容記述 | Runx2 is a transcription factor that belongs to Runx family (Runx1, Runx2, and Runx3). Runx2 interacts with many other transcription factors and co-regulators in the transcriptional regulation of its target genes. Cbfb is one of the co-regulators, forms heterodimers with Runx2, and is required for Runx2-dependent transcriptional regulation. Runx2 is essential for the commitment of multipotent mesenchymal cells into the osteoblastic lineage, because Runx2-deficient mice show complete lack of bone formation due to the absence of osteoblasts. Further, Runx2 inhibits adipocyte differentiation, because Runx2-deficient calvarial cells spontaneously differentiate into adipocytes. Overexpression of Runx2 in osteoblasts inhibits osteoblast maturation but decreased the expression of major bone matrix protein genes. Therefore, Runx2 triggers the gene expression of bone matrix proteins, while keeping the osteoblastic cells in an immature stage. Moreover, Runx2 strongly inhibits the transition of osteoblasts into osteocytes. Runx2 and Runx3 double knockout mice showed that Runx2 and Runx3 have redundant functions in chondrocytes, and that they are essential for chondrocyte maturation. Runx2 directly induces Ihh expression and coordinates the proliferation and differentiation of chondrocytes. Therefore, Runx2 regulates bone formation by regulating osteoblast differentiation as well as chondrocyte maturation. | |||||||
| 言語 | en | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_5794 | |||||||
| 資源タイプ | conference paper | |||||||
| 出版タイプ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
| 関連情報 | ||||||||
| 関連タイプ | isPartOf | |||||||
| 識別子タイプ | URI | |||||||
| 関連識別子 | http://ir.lib.hiroshima-u.ac.jp/00014842 | |||||||
| 開始ページ | ||||||||
| 開始ページ | 133 | |||||||
| 書誌情報 |
Hiroshima Conference on Education and Science in Dentistry, 2006 : the 40th Anniversary of Hiroshima University Faculty of Dentistry Hiroshima Conference on Education and Science in Dentistry, 2006 : the 40th Anniversary of Hiroshima University Faculty of Dentistry p. 133-136, 発行日 2006-01-08 |
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| 旧ID | 106 | |||||||
