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Regulation of hematopoietic stem cell and its interaction with stem cell niche

https://hiroshima.repo.nii.ac.jp/records/2000940
https://hiroshima.repo.nii.ac.jp/records/2000940
96226681-daf7-4b62-89e0-5129c20cd3d4
名前 / ファイル ライセンス アクション
Symp-Edu-Sci_50-56.pdf Symp-Edu-Sci_50-56.pdf (4.0 MB)
Item type デフォルトアイテムタイプ_(フル)(1)
公開日 2023-03-18
タイトル
タイトル Regulation of hematopoietic stem cell and its interaction with stem cell niche
言語 en
作成者 Arai, Fumio

× Arai, Fumio

en Arai, Fumio

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
主題
主題Scheme Other
主題 Quiescence
主題
主題Scheme Other
主題 Tie2
主題
主題Scheme Other
主題 Angiopoietin-1
主題
主題Scheme Other
主題 N-cadherin
主題
主題Scheme Other
主題 ATM
主題
主題Scheme NDC
主題 490
内容記述
内容記述 Hematopoietic stem cells (HSCs) are responsible for Blood cell production throughout the lifetime of individuals. Interaction of HSCs with their particular microenvironments, known as stem cell niches, is critical for maintaining the stem cell properties, including self-renewal capacity and the ability of differentiation into single or multiple lineages. In the niche, the niche cells produce signaling molecules, extracellular matrix, and cell adhesion molecules, and regulate stem cell fates. Recently, long-term bone marrow (BM) repopulating (LTR) HSCs exist frequently in BM trabecular bone surface, and it was clarified that an osteoblast (OB) is a critical component for sustainment of HSCs. HSCs balance quiescence and cell division in the osteoblastic niche and also maintain the potential for long-term hematopoiesis. Especially, the quiescent state in the cell cycle is thought to be indispensable for the maintenance of hematopoietic stem cells (HSCs). We demonstrate that c-Kit+Sca-1+Lineage- (KSL) HSCs expressing the receptor tyrosine kinase Tie2 are quiescent and anti-apoptotic, transplantable and comprise a side-population (SP) of HSCs, which contact closely to Angiopoietin-1 (Ang-1), a ligand for Tie2, expressing osteoblasts in the BM niche. Tie2 and Ang-1 are part of a key signaling interaction between HSC and osteoblasts. Tie2 and Ang-1 are expressed in a complementary pattern, and interaction of Tie2 and Ang-1 induced integrin dependent cell adhesion of HSCs to osteoblasts and extracellular matrix. This signaling pathway regulates functional criteria of HSC in the BM niche, including quiescence, anti-cell death and tight adhesion. These observations led us to a novel model in which Ang-1 produced by osteoblasts activates Tie2 on the HSCs and promote tight adhesion of HSCs to the niche, resulting in quiescence and enhanced survival of HSCs.
言語 en
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_5794
資源タイプ conference paper
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
開始ページ
開始ページ 50
書誌情報 Hiroshima Conference on Education and Science in Dentistry, 2006 : the 40th Anniversary of Hiroshima University Faculty of Dentistry
Hiroshima Conference on Education and Science in Dentistry, 2006 : the 40th Anniversary of Hiroshima University Faculty of Dentistry

p. 50-56, 発行日 2006-01-08
旧ID 96
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