| Item type |
デフォルト(1) |
| 公開日 |
2025-06-25 |
| タイトル |
|
|
タイトル |
The Dominant Component and Clinicopathological Characteristics of Combined Hepatocellular-cholangiocarcinoma After Radical Resection |
|
言語 |
en |
| 作成者 |
MATSUBARA, KEISO
KOBAYASHI, TSUYOSHI
TADOKORO, TAKESHI
NAMBA, YOSUKE
FUKUHARA, SOTARO
OSHITA, KO
HONMYO, NARUHIKO
KURODA, SHINTARO
ARIHIRO, KOJI
OHDAN, HIDEKI
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
© 2024 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved. |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
This is not the published version. Please cite only the published version. |
| 権利情報 |
|
|
言語 |
ja |
|
権利情報 |
この論文は出版社版ではありません。引用の際には出版社版をご確認、ご利用ください。 |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Hepatocellular carcinoma |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
cholangiocarcinoma |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
classification |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
hepatectomy |
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Background/Aim: Combined hepatocellular cholangiocarcinoma (cHCC-CCA) is a rare subtype of primary liver carcinoma, characterized by the unequivocal presence of both hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA). However, its clinicopathological characteristics have not yet been thoroughly elucidated. In particular, cholangiolocellular carcinoma (CLC) was classified as a subtype of cHCC-CCA according to the 2010 World Health Organization (WHO) classification. However, according to the 2019 WHO classification, tumors displaying histological features consistent with CLC but lacking evidence of hepatocellular differentiation should be regarded as a distinct subtype of iCCA. Nevertheless, there may be notable differences in prognosis between CLC and iCCA, indicating the necessity for refining the classification when devising clinical treatment strategies. This study aimed to determine the clinicopathological features and prognostic factors of cHCC-CCAs following radical resection. Patients and Methods: Between January 2010 and September 2020, based on the 2010 WHO classification, we retrospectively studied the clinicopathological features and prognoses of patients with cHCC-CCAs in relation to the pathological dominant classification. The patients were classified according to the pathological dominant components of cHCC-CCA as HCC-dominant (HCC-D), iCCA-dominant (iCCA-D), or CLC-dominant (CLC-D). Results: Data of 55 patients who underwent primary radical hepatectomy for cHCC-CCA were analyzed. The prevalences of each dominant classification were HCC-D, 21 (38.2%); iCCA-D, 11 (20.0%); and CLC-D, 23 (41.8%). Multivariate analysis showed that dominant classification was an independent risk factor for recurrence and cancer-specific survival (CSS). Conclusion: The dominant classification of cHCC-CCA has the potential to predict recurrence and CSS. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
International Institute of Anticancer Research |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 関連情報 |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.21873/anticanres.17284 |
| 助成情報 |
|
|
|
助成機関識別子タイプ |
Crossref Funder |
|
|
助成機関識別子タイプURI |
https://doi.org/10.13039/100009619 |
|
|
助成機関名 |
日本医療研究開発機構 |
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|
言語 |
ja |
|
|
助成機関名 |
Japan Agency for Medical Research and Development (AMED) |
|
|
言語 |
en |
|
|
研究課題番号 |
22FK0210108 |
|
|
研究課題名 |
分化制御NK細胞を用いた免疫療法による新規肝炎/肝癌治療の開発研究 |
|
|
言語 |
ja |
| 書誌情報 |
en : Anticancer Research
巻 44,
号 10,
p. 4551-4559,
発行日 2024-09-30
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AnticancerRes_44_4551.pdf (868 KB)
