| Item type |
デフォルト(1) |
| 公開日 |
2025-06-04 |
| タイトル |
|
|
タイトル |
Gigantolevisins A–C, tyrosinase inhibitory benzylidenes from the shoots of Gigantochloa levis |
|
言語 |
en |
| 作成者 |
Sagaral-Lacandalo, Lina
Gelani, Chona D.
Ohta, Emi
Ohta, Shinji
|
| アクセス権 |
|
|
アクセス権 |
embargoed access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_f1cf |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
© 2024. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
This is not the published version. Please cite only the published version. |
| 権利情報 |
|
|
言語 |
ja |
|
権利情報 |
この論文は出版社版ではありません。引用の際には出版社版をご確認、ご利用ください。 |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Gigantochloa levis |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Poaceae |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Bamboo shoots |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Benzylidene derivatives |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Tyrosinase |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Inhibitors |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Gigantolevisin |
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
The excessive tyrosinase activity has been linked to the overproduction of melanin which can lead to hyperpigmentation, oxidative stress, browning, and an increased risk of melanoma. Due to these detrimental effects associated with the overexpression of tyrosinase, research efforts are focused on finding bioactive compounds that can inhibit this enzyme efficiently. This study, conducted to find tyrosinase inhibitors utilizing the shoots of Gigantochloa levis (G. levis), produced three previously undescribed benzylidene derivatives (1–3) and two known compounds, with promising anti-tyrosinase activity. The new compounds were designated as gigantolevisins A–C, and the two known compounds as (E)-3-(4-hydroxyphenyl)-2-phenylacrylaldehyde (4) and (E)-2,3-bis(4-hydroxyphenyl)acrylaldehyde (5), respectively, based on the spectroscopic data and X-ray crystallographic analysis. The isolated compounds showed inhibition effects against tyrosinase, ranging from 42 % to 58 % (IC50 values of >400–286 ± 15 μM) in comparison to the positive control Kojic acid with 100 % inhibition (IC50 value of 43 ± 3 μM). The findings suggest that, while the isolated compounds are less potent than Kojic acid, they can be effective in inhibiting tyrosinase activity. Thus, the study highlights the therapeutic potential of G. levis shoots for treating melanin-related conditions. |
|
言語 |
en |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
This research work was financially subsidized by the Department of Science and Technology (DOST), Philippines under the Accelerated Science and Technology Human Resource Development Program (ASTHRDP). |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Elsevier |
|
言語 |
en |
| 日付 |
|
|
日付 |
2026-10-19 |
|
日付タイプ |
Available |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 関連情報 |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1016/j.phytol.2024.10.003 |
| 書誌情報 |
en : Phytochemistry Letters
巻 64,
p. 86-92,
発行日 2024-10-19
|
| 備考 |
|
|
言語 |
en |
|
値 |
The full-text file will be made open to the public on 19 October 2026 in accordance with publisher's 'Terms and Conditions for Self-Archiving' |
PhytochemLett_64_86.pdf (2.9 MB)
