{"created":"2025-05-30T07:25:54.931348+00:00","id":2040682,"links":{},"metadata":{"_buckets":{"deposit":"a8193cd8-f613-4937-83ea-2025cda4d84d"},"_deposit":{"created_by":83,"id":"2040682","owner":"83","owners":[83],"pid":{"revision_id":0,"type":"depid","value":"2040682"},"status":"published"},"_oai":{"id":"oai:hiroshima.repo.nii.ac.jp:02040682","sets":["1730444907710"]},"author_link":[],"control_number":"2040682","item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"Cell type-specific contribution to the initiation of cortical spreading depolarization in the mouse","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Handa, Takashi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Zhang, Qing","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ma, Zhongqi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Aizawa, Hidenori","creatorNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_access_right":"embargoed access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_f1cf"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"©［ 2025］. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/","subitem_rights_language":"en"},{"subitem_rights":"This is not the published version. Please cite only the published version.","subitem_rights_language":"en"},{"subitem_rights":"この論文は出版社版ではありません。引用の際には出版社版をご確認、ご利用ください。","subitem_rights_language":"ja"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"Cortical spreading depolarization (CSD) is a wave of transient depolarization in the neuronal and glial cells and plays a role in the pathophysiological process implicated in a number of diseases, including migraine aura, ischemic stroke and traumatic brain injury. Despite its clinical significance, the cellular mechanism underlying the initiation of CSD remains unclear. Since the mammalian cerebral cortex consists of excitatory pyramidal cells and diverse types of inhibitory interneurons, addressing their roles would be of primary importance in understanding CSD generation. In the current study, we showed the differential temporal dynamics of three cell types in the murine cortex upon the initiation of CSD using electrophysiological and histological analyses. Results showed upregulation of the firing rate with reduced spike-local field potential (LFP) coherence of all cell types in the slow wave range in the hemisphere ipsilateral to the CSD without affecting them in the contralateral hemisphere. Specifically, upon initiation of CSD, fast spiking (FS) interneurons were actively involved in local network activity with increased spike-LFP coherence in the gamma range and led a quasi-synchronous activation of the cortical neurons by showing a preceding increase of the firing activity over the other cell types. Histological analysis showed that these activated FS cells were localized in the cortical layers III and IV. These results highlighted the roles of the FS inhibitory interneuron and its interaction with the other types of cells upon the generation of CSD.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"This work was partly supported by JSPS KAKENHI 19H0572301, 21H02581 and 23K18256 to HA, JSPS KAKENHI 22K06485 to TH, Astellas Foundation for Research on Metabolic Disorders to HA and SENSHIN Medical Research Foundation to HA.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"}]},"item_1617186660861":{"attribute_name":"Date","attribute_value_mlt":[{"subitem_date_issued_datetime":"2026-01-31","subitem_date_issued_type":"Available"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617186901218":{"attribute_name":"Funding 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