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Cell type-specific contribution to the initiation of cortical spreading depolarization in the mouse
https://hiroshima.repo.nii.ac.jp/records/2040682
https://hiroshima.repo.nii.ac.jp/records/2040682cb0f8af1-026c-4bd1-a89b-e35eed8fedae
| 名前 / ファイル | ライセンス | アクション |
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BBRC_751_151428.docx (107 KB)
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data.zip (56.6 MB)
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| Item type | デフォルト(1) | |||||||||||||
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| 公開日 | 2025-06-03 | |||||||||||||
| タイトル | ||||||||||||||
| タイトル | Cell type-specific contribution to the initiation of cortical spreading depolarization in the mouse | |||||||||||||
| 言語 | en | |||||||||||||
| 作成者 |
Handa, Takashi
× Handa, Takashi
× Zhang, Qing
× Ma, Zhongqi
× Aizawa, Hidenori
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| アクセス権 | ||||||||||||||
| アクセス権 | embargoed access | |||||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_f1cf | |||||||||||||
| 権利情報 | ||||||||||||||
| 言語 | en | |||||||||||||
| 権利情報 | ©［ 2025］. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||||||||||
| 権利情報 | ||||||||||||||
| 言語 | en | |||||||||||||
| 権利情報 | This is not the published version. Please cite only the published version. | |||||||||||||
| 権利情報 | ||||||||||||||
| 言語 | ja | |||||||||||||
| 権利情報 | この論文は出版社版ではありません。引用の際には出版社版をご確認、ご利用ください。 | |||||||||||||
| 内容記述 | ||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||
| 内容記述 | Cortical spreading depolarization (CSD) is a wave of transient depolarization in the neuronal and glial cells and plays a role in the pathophysiological process implicated in a number of diseases, including migraine aura, ischemic stroke and traumatic brain injury. Despite its clinical significance, the cellular mechanism underlying the initiation of CSD remains unclear. Since the mammalian cerebral cortex consists of excitatory pyramidal cells and diverse types of inhibitory interneurons, addressing their roles would be of primary importance in understanding CSD generation. In the current study, we showed the differential temporal dynamics of three cell types in the murine cortex upon the initiation of CSD using electrophysiological and histological analyses. Results showed upregulation of the firing rate with reduced spike-local field potential (LFP) coherence of all cell types in the slow wave range in the hemisphere ipsilateral to the CSD without affecting them in the contralateral hemisphere. Specifically, upon initiation of CSD, fast spiking (FS) interneurons were actively involved in local network activity with increased spike-LFP coherence in the gamma range and led a quasi-synchronous activation of the cortical neurons by showing a preceding increase of the firing activity over the other cell types. Histological analysis showed that these activated FS cells were localized in the cortical layers III and IV. These results highlighted the roles of the FS inhibitory interneuron and its interaction with the other types of cells upon the generation of CSD. | |||||||||||||
| 言語 | en | |||||||||||||
| 内容記述 | ||||||||||||||
| 内容記述タイプ | Other | |||||||||||||
| 内容記述 | This work was partly supported by JSPS KAKENHI 19H0572301, 21H02581 and 23K18256 to HA, JSPS KAKENHI 22K06485 to TH, Astellas Foundation for Research on Metabolic Disorders to HA and SENSHIN Medical Research Foundation to HA. | |||||||||||||
| 言語 | en | |||||||||||||
| 出版者 | ||||||||||||||
| 出版者 | Elsevier | |||||||||||||
| 言語 | en | |||||||||||||
| 日付 | ||||||||||||||
| 日付 | 2026-01-31 | |||||||||||||
| 日付タイプ | Available | |||||||||||||
| 言語 | ||||||||||||||
| 言語 | eng | |||||||||||||
| 資源タイプ | ||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||
| 資源タイプ | journal article | |||||||||||||
| 出版タイプ | ||||||||||||||
| 出版タイプ | AM | |||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||
| 関連情報 | ||||||||||||||
| 関連タイプ | isVersionOf | |||||||||||||
| 識別子タイプ | DOI | |||||||||||||
| 関連識別子 | http://dx.doi.org/10.1016/j.bbrc.2025.151428 | |||||||||||||
| 助成情報 | ||||||||||||||
| 助成機関識別子タイプ | Crossref Funder | |||||||||||||
| 助成機関識別子タイプURI | https://doi.org/10.13039/501100001691 | |||||||||||||
| 助成機関名 | 日本学術振興会 | |||||||||||||
| 言語 | ja | |||||||||||||
| 助成機関名 | Japan Society for the Promotion of Science | |||||||||||||
| 言語 | en | |||||||||||||
| 研究課題番号URI | https://kaken.nii.ac.jp/ja/grant/KAKENHI-PLANNED-19H05723/ | |||||||||||||
| 研究課題番号 | 19H05723 | |||||||||||||
| 研究課題名 | 生体構造の再構成による超適応機構の解明と潜在適応力低下防止への挑戦 | |||||||||||||
| 言語 | ja | |||||||||||||
| 研究課題名 | Elucidation of the hyper-adaptation mechanism by reconstruction of bio-structure and challenges for prevention of decline in latent adaptive capacity | |||||||||||||
| 言語 | en | |||||||||||||
| 助成情報 | ||||||||||||||
| 助成機関識別子タイプ | Crossref Funder | |||||||||||||
| 助成機関識別子タイプURI | https://doi.org/10.13039/501100001691 | |||||||||||||
| 助成機関名 | 日本学術振興会 | |||||||||||||
| 言語 | ja | |||||||||||||
| 助成機関名 | Japan Society for the Promotion of Science | |||||||||||||
| 言語 | en | |||||||||||||
| 研究課題番号URI | https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-21H02581/ | |||||||||||||
| 研究課題番号 | 21H02581 | |||||||||||||
| 研究課題名 | うつ病様行動異常における手綱核神経炎症の役割 | |||||||||||||
| 言語 | ja | |||||||||||||
| 研究課題名 | Inflammatory response of the habenula underlying depressive-like behaviors | |||||||||||||
| 言語 | en | |||||||||||||
| 助成情報 | ||||||||||||||
| 助成機関識別子タイプ | Crossref Funder | |||||||||||||
| 助成機関識別子タイプURI | https://doi.org/10.13039/501100001691 | |||||||||||||
| 助成機関名 | 日本学術振興会 | |||||||||||||
| 言語 | ja | |||||||||||||
| 助成機関名 | Japan Society for the Promotion of Science | |||||||||||||
| 言語 | en | |||||||||||||
| 研究課題番号URI | https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-23K18256/ | |||||||||||||
| 研究課題番号 | 23K18256 | |||||||||||||
| 研究課題名 | 脳内ドーパミンの操作による勇敢な行動の誘導 | |||||||||||||
| 言語 | ja | |||||||||||||
| 研究課題名 | Induction of courageous behavior by modulation of dopamine release in the brain | |||||||||||||
| 言語 | en | |||||||||||||
| 助成情報 | ||||||||||||||
| 助成機関識別子タイプ | Crossref Funder | |||||||||||||
| 助成機関識別子タイプURI | https://doi.org/10.13039/501100001691 | |||||||||||||
| 助成機関名 | 日本学術振興会 | |||||||||||||
| 言語 | ja | |||||||||||||
| 助成機関名 | Japan Society for the Promotion of Science | |||||||||||||
| 言語 | en | |||||||||||||
| 研究課題番号URI | https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-22K06485/ | |||||||||||||
| 研究課題番号 | 22K06485 | |||||||||||||
| 研究課題名 | 大脳皮質－線条体経路特異的な光遺伝学的操作による適応行動の神経機序の解明 | |||||||||||||
| 言語 | ja | |||||||||||||
| 収録物識別子 | ||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||
| 収録物識別子 | 0006-291X | |||||||||||||
| 書誌情報 |
en : BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 巻 751, p. 151428, 発行日 2025-01-31 |
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| 備考 | ||||||||||||||
| 言語 | en | |||||||||||||
| 値 | The full-text file will be made open to the public on [31 Jan 2026］ in accordance with publisher's 'Terms and Conditions for Self-Archiving' | |||||||||||||
