| Item type |
デフォルト(1) |
| 公開日 |
2025-06-02 |
| タイトル |
|
|
タイトル |
Clinical significance and biological role of claudin-1 in oral squamous cell carcinoma cells |
|
言語 |
en |
| 作成者 |
Nobumoto, Tadayoshi
Yamaki, Sachiko
Hamada, Atsuko
Higaki, Mirai
Ito, Nanako
Obayashi, Fumitaka
Ishida, Yasutaka
Hamana, Tomoaki
Shintani, Tomoaki
Tani, Ryouji
Koizumi, Koichi
Yanamoto, Souichi
Hayashido, Yasutaka
|
| アクセス権 |
|
|
アクセス権 |
embargoed access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_f1cf |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
©［ 2024］. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
This is not the published version. Please cite only the published version. |
| 権利情報 |
|
|
言語 |
ja |
|
権利情報 |
この論文は出版社版ではありません。引用の際には出版社版をご確認、ご利用ください |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
claudin1 |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
beta-catenin |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
oral squamous cell carcinoma |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
prognosis |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
tight junctions |
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Objectives
Claudin (CLD), a major component of tight junctions, is a four-transmembrane protein, and 24 subtypes have been reported in humans. CLD expression is highly tissue-specific; CLD1 has been reported to be expressed in the skin and mucosa. There have been few reports on CLD1 expression and its function in oral cancer.
Materials and methods
This retrospective study immunohistochemically evaluated CLD1 expression as prognostic predictors in 84 participants with oral squamous cell carcinoma (OSCC). Participants were classified as positive or negative based on staining intensity; the clinicopathologic characteristics and survival rates of the two groups were compared. To clarify the biological role of CLD1 in OSCC cells, we examined the effects of CLD1 overexpression on the invasion and proliferation of the OSCC cell line, SCCKN.
Results
We observed the immunohistochemical CLD1 expression in the cell membranes of OSCC cells. The disease-free survival rate was significantly lower in patients with CLD1-positive OSCC than in patients with CLD1-negative OSCC (P < .05). In vitro studies showed that cell proliferative capacity, motility, proteolytic activity, and invasive growth were promoted in CLD1-overexpressing SCCKN cells compared to those in control SCCKN cells.
Conclusion
CLD1 may be a useful and potential prognostic factor for OSCC treatment. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Elsevier |
|
言語 |
en |
| 日付 |
|
|
日付 |
2025-09-03 |
|
日付タイプ |
Available |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 関連情報 |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
http://dx.doi.org/10.1016/j.oooo.2024.08.020 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
2212-4411 |
| 書誌情報 |
en : ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
巻 139,
号 1,
p. 92-100,
発行日 2024-09-03
|
| 備考 |
|
|
言語 |
en |
|
値 |
The full-text file will be made open to the public on [03 Sep 2025］ in accordance with publisher's 'Terms and Conditions for Self-Archiving' |
OSOMOPOR_139_1_92.docx (6 MB)
