| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2025-01-30 |
| タイトル |
|
|
タイトル |
Utility of microRNA analysis using liquid-based cytology samples for uterine endometrial cancer screening |
|
言語 |
en |
| 作成者 |
NOSAKA, Suguru
KUDO, Yoshiki
UCHIHATA-OHUE, Yukari
ARIHIRO, Koji
SEKINE, Masaki
TOMONO, Katsuyuki
KOH, Iemasa
SUGIMOTO, Jun
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
Copyright (c) 2024 Hiroshima University Medical Press |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Uterine endometrial cancer |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Screening |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
microRNA |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
LBC |
| 内容記述 |
|
|
内容記述 |
Objectives: This study was performed to investigate microRNA (miRNA) expression in cytological specimens processed under clinical conditions to determine the potential of miRNA detection as a diagnostic biomarker of uterine endometrial cancer. Methods: We collected 40 lysates from cytology (LBC) specimens obtained during screening for endometrial cancer and normal endometrium, 18 surgically resected tissue specimens containing endometrial cancer and normal endometrium, and 14 LBC specimens of equivocal diagnosis at Hiroshima University Hospital. We compared the expression of four miRNAs (miR-96, miR-182, miR-183, and miR-143) and selected two (miR-96 and miR-143) that we predicted would be useful. Results: We confirmed that miR-96 expression was significantly elevated and miR-143 expression was significantly depressed in cancer samples relative to normal endometrial samples. Among the 14 LBC specimens diagnosed with equivocal results, seven were pathologically diagnosed with cancer and showed the same profile as described above. Conclusions: Our data suggest that miRNA analysis of LBC samples may be useful for endometrial cancer screening. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Hiroshima University Medical Press |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 開始ページ |
|
|
開始ページ |
29 |
| 書誌情報 |
en : Hiroshima Journal of Medical Sciences
巻 73,
号 3-4,
p. 29-34,
発行日 2024-12
|
| 旧ID |
56193 |
HiroshimaJMedSci_73_29.pdf (1.8 MB)
