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The Effectiveness of Phaleria Macrocarpa and Chemotherapy in Increasing Caspase 3 and Apoptotic Index in Epidermoid Carcinoma
https://hiroshima.repo.nii.ac.jp/records/2013780
https://hiroshima.repo.nii.ac.jp/records/2013780f2aeaa03-25af-4f56-91e6-d4c8a4c898f1
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
HiroshimaJMedSci_67s_153.pdf (1.1 MB)
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| Item type | デフォルトアイテムタイプ_（フル）(1) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2023-03-18 | |||||||||||
| タイトル | ||||||||||||
| タイトル | The Effectiveness of Phaleria Macrocarpa and Chemotherapy in Increasing Caspase 3 and Apoptotic Index in Epidermoid Carcinoma | |||||||||||
| 言語 | en | |||||||||||
| 作成者 |
Sastriawan, Helmi
× Sastriawan, Helmi
× Arifin, Muhamad Thohar
× Handojo, Djoko
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| アクセス権 | ||||||||||||
| アクセス権 | open access | |||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||
| 権利情報 | ||||||||||||
| 権利情報 | Copyright (c) 2018 Hiroshima University Medical Press | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Phaleria marcocarpa | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | caspase 3 | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | apoptotic index | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | epidermoid carcinoma of the skin | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | NDC | |||||||||||
| 主題 | 490 | |||||||||||
| 内容記述 | ||||||||||||
| 内容記述 | Chemotherapy management of epidermoid carcinoma of the skin is relatively expensive and has toxic effects on vital organs. Phaleria macrocarpa is a medicinal plant that is often used as an anti-cancer. This study aims to prove the effectiveness of the Phaleria marcocarpa extract, paclitaxel-cisplatin chemotherapy and the combination of both as a neoadjuvant to increase caspase-3 expression and apoptotic index in epidermoid carcinoma of the skin in Swiss male mice. This study used male mice of the Swiss strain, after induction of epidermoid carcinoma cells, 4 group randomization, K (control), P1 (Phaleria macrocarpa 0.0715 mg/ day), P2 (paclitaxel 175 mg/m2 and cisplatin 50 mg/m2), P3 (the combination of Phaleria macrocarpa and chemotherapy). The caspase-3 expression was examined with immunohistochemical stain and the apoptotic index examination was done by staining the Tunel. The research shows that there is an increase in caspase-3 expression; the order of the increase (from the most significant to the less significant) is P3, P2, and P1 with significant result (p<0.05) compraed to the control group. There is a significant correlation between caspase-3 expression and apoptotic index with a very strong positive correlation. It can be concluded that the Phaleria marcocarpa extract, paclitaxel-cisplatin chemotherapy and the combination of both increased the caspase-3 expression and the apoptotic index of epidermoid carcinoma cell; there was no significant differences between P1 and P2 but there was a synergy effect from the administration of P1 and P2 combination, and there was significant correlation between the caspase-3 expression and apoptotic index with a very strong positive correlation. | |||||||||||
| 言語 | en | |||||||||||
| 出版者 | ||||||||||||
| 出版者 | Hiroshima University Medical Press | |||||||||||
| 言語 | ||||||||||||
| 言語 | eng | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
| 資源タイプ | departmental bulletin paper | |||||||||||
| 出版タイプ | ||||||||||||
| 出版タイプ | VoR | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||
| 収録物識別子 | ||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||
| 収録物識別子 | 0018-2052 | |||||||||||
| 収録物識別子 | ||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||
| 収録物識別子 | AA00664312 | |||||||||||
| 開始ページ | ||||||||||||
| 開始ページ | 153 | |||||||||||
| 書誌情報 |
Hiroshima Journal of Medical Sciences Hiroshima Journal of Medical Sciences 巻 67, p. 153-160, 発行日 2018-05 |
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| 旧ID | 45859 | |||||||||||
