| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
P-Selectin as Predictor Venous Thromboembolism in Cancer Patients Undergoing Chemotherapy |
|
言語 |
en |
| 作成者 |
Suharti, C.
Santosa
Pangarso, Eko Adhi
Setiawan, Budi
Samakto, Baringin de
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
権利情報 |
Copyright (c) 2018 Hiroshima University Medical Press |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
venous thromboembolism |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
sP-selectin |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
cancer |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
chemotherapy |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
|
|
内容記述 |
Background: Venous thromboembolism (VTE), consisting of deep vein thrombosis (DVT) and pulmonary embolism (PE), is the second-leading cause of death in patients with malignancy. P-selectin, the member of the selectin family of cell adhesion molecules, is found in the alpha granules of platelets and the Weibel-Palade bodies of endothelial cells. It is express on the cell surface on activation, mediates the adhesion of leukocytes, platelets, and cancer cells in inflammation, thrombosis, and cancer growth and metastasis. Recently, P-selectin has been investigated as a novel predictor for DVT. Objectives: To investigate the role of sP-selectin as predictors of DVT in cancer patients undergoing chemotherapy. Patients and Methods: This prospective cohort study was conducted in Dr. Kariadi hospital, Semarang, Indonesia, on 40 newly diagnosed cancer patients. Venous blood samples were drawn prior and after initial chemotherapy, for sP-selectin measurement with ELISA method. These patients were observed for the possibility of developing VTE during three-months period. Results: DVT occurred in 5 (12.5%) patients after a median period of 8 weeks. The most frequent cancer type was colorectal cancer (45%) and cervical cancer (15%). The cut-off point sP-selectin pre-and post- chemotherapy were 106,7 ng/ml and 111,7 ng/ml respectively. The median levels of sP-selectin in DVT patients pre-chemotherapy was 121.0ng/ml (IQR 107.5-230.6) and post-chemotherapy was 204.4ng/ml (IQR 110.9-278.3). In other hand, the median levels of sP- selectin pre-chemotherapy and post- chemotherapy in DVT negative patients were 82.0ng/ml (IQR 31.3-230.6) and 92.5 (IQR 40.9-278.3), respectively. With cut-off point sP-selectin level 111,7 ng/ml, the relative risk of DVT event was 8,7 (95% CI 1,017-74,39). Conclusion: In this study, high plasma levels of s P-selectin are predictive for venous thromboembolism in cancer patients undergoing chemotherapy. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Hiroshima University Medical Press |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0018-2052 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00664312 |
| 開始ページ |
|
|
開始ページ |
15 |
| 書誌情報 |
Hiroshima Journal of Medical Sciences
Hiroshima Journal of Medical Sciences
巻 67,
p. 15-20,
発行日 2018-05
|
| 旧ID |
45838 |
HiroshimaJMedSci_67s_15.pdf (237.7 KB)
