{"created":"2025-02-23T06:41:12.067656+00:00","id":2013707,"links":{},"metadata":{"_buckets":{"deposit":"ce233e9d-3701-46c6-9472-0c0160a9a4e0"},"_deposit":{"created_by":41,"id":"2013707","owners":[41],"pid":{"revision_id":0,"type":"depid","value":"2013707"},"status":"published"},"_oai":{"id":"oai:hiroshima.repo.nii.ac.jp:02013707","sets":["1727147343679:1730442224523:1730442242406"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"The Sarin-like Organophosphorus Agent bis(isopropyl methyl)phosphonate Induces Apoptotic Cell Death and COX-2 Expression in SK-N-SH Cells","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Arima, Yosuke","creatorNameLang":"en"}],"familyNames":[{"familyName":"Arima","familyNameLang":"en"}],"givenNames":[{"givenName":"Yosuke","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Yoshimoto, Kanji","creatorNameLang":"en"}],"familyNames":[{"familyName":"Yoshimoto","familyNameLang":"en"}],"givenNames":[{"givenName":"Kanji","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Namera, Akira","creatorNameLang":"en"}],"familyNames":[{"familyName":"Namera","familyNameLang":"en"}],"givenNames":[{"givenName":"Akira","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Makita, Ryosuke","creatorNameLang":"en"}],"familyNames":[{"familyName":"Makita","familyNameLang":"en"}],"givenNames":[{"givenName":"Ryosuke","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Murata, Kazuhiro","creatorNameLang":"en"}],"familyNames":[{"familyName":"Murata","familyNameLang":"en"}],"givenNames":[{"givenName":"Kazuhiro","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Nagao, Masataka","creatorNameLang":"en"}],"familyNames":[{"familyName":"Nagao","familyNameLang":"en"}],"givenNames":[{"givenName":"Masataka","givenNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"Copyright (c) 2016 Hiroshima University Medical Press"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"Sarin","subitem_subject_scheme":"Other"},{"subitem_subject":"Organophosphates","subitem_subject_scheme":"Other"},{"subitem_subject":"Apoptosis","subitem_subject_scheme":"Other"},{"subitem_subject":"COX-2","subitem_subject_scheme":"Other"},{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"Organophosphorus compounds, such as sarin, are highly toxic nerve agents that inhibit acetylcholinesterase (AChE), but not cholinesterase, via multiple mechanisms. Recent studies have shown that organophosphorus compounds increase cyclooxygenase-2 (COX-2) expression and induce neurotoxicity. In this study, we examined the toxicity of the sarin-like organophosphorus agent bis(isopropyl methyl)phosphonate (BIMP) and the effects of BIMP on COX-2 expression in SK-N-SH human neuroblastoma cells. Exposure to BIMP changed cell morphology and induced caspase-dependent apoptotic cell death accompanied by cleavage of caspase 3, caspase 9, and poly (ADP-ribose) polymerase (PARP). It also increased COX-2 expression, while pretreatment with a COX inhibitor, ibuprofen, decreased BIMP-dependent cell death and COX-2 expression in SK-N-SH cells. Thus, our findings suggest that BIMP induces apoptotic cell death and upregulates COX-2 expression.","subitem_description_language":"en"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Hiroshima University Medical Press"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_source_identifier":"0018-2052","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA00664312","subitem_source_identifier_type":"NCID"}]},"item_1617187024783":{"attribute_name":"開始ページ","attribute_value_mlt":[{"subitem_start_page":"1"}]},"item_1617187056579":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"8","bibliographicPageStart":"1","bibliographicVolumeNumber":"65","bibliographic_titles":[{"bibliographic_title":"Hiroshima Journal of Medical Sciences"},{"bibliographic_title":"Hiroshima Journal of Medical Sciences"}]}]},"item_1617258105262":{"attribute_name":"item_1617258105262","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-03-18"}],"displaytype":"simple","filename":"HiroshimaJMedSci_65_1.pdf","filesize":[{"value":"811.5 KB"}],"mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hiroshima.repo.nii.ac.jp/record/2013707/files/HiroshimaJMedSci_65_1.pdf"},"version_id":"2184f825-d39e-443c-b690-10e5139fe463"}]},"item_1732771732025":{"attribute_name":"旧ID","attribute_value":"39746"},"item_title":"The Sarin-like Organophosphorus Agent bis(isopropyl methyl)phosphonate Induces Apoptotic Cell Death and COX-2 Expression in SK-N-SH Cells","item_type_id":"40003","owner":"41","path":["1730442242406"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-03-18"},"publish_date":"2023-03-18","publish_status":"0","recid":"2013707","relation_version_is_last":true,"title":["The Sarin-like Organophosphorus Agent bis(isopropyl methyl)phosphonate Induces Apoptotic Cell Death and COX-2 Expression in SK-N-SH Cells"],"weko_creator_id":"41","weko_shared_id":-1},"updated":"2025-06-02T03:29:16.450644+00:00"}