{"created":"2025-02-23T06:40:21.363433+00:00","id":2013678,"links":{},"metadata":{"_buckets":{"deposit":"89237c4b-0904-43d0-ac31-0b385e03be4b"},"_deposit":{"created_by":41,"id":"2013678","owners":[41],"pid":{"revision_id":0,"type":"depid","value":"2013678"},"status":"published"},"_oai":{"id":"oai:hiroshima.repo.nii.ac.jp:02013678","sets":["1727147343679:1730442224523:1730442249437"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"TIMP-1 c.T372C Genetic Polymorphism as a Possible Predictor for Acute Aortic Dissection","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Naychov, Zheko Dimirtov","creatorNameLang":"en"}],"familyNames":[{"familyName":"Naychov","familyNameLang":"en"}],"givenNames":[{"givenName":"Zheko Dimirtov","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hiyama, Eiso","creatorNameLang":"en"}],"familyNames":[{"familyName":"Hiyama","familyNameLang":"en"}],"givenNames":[{"givenName":"Eiso","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Uchida, Naomichi","creatorNameLang":"en"}],"familyNames":[{"familyName":"Uchida","familyNameLang":"en"}],"givenNames":[{"givenName":"Naomichi","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Arihiro, Koji","creatorNameLang":"en"}],"familyNames":[{"familyName":"Arihiro","familyNameLang":"en"}],"givenNames":[{"givenName":"Koji","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Nagao, Masataka","creatorNameLang":"en"}],"familyNames":[{"familyName":"Nagao","familyNameLang":"en"}],"givenNames":[{"givenName":"Masataka","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Takahashi, Shinya","creatorNameLang":"en"}],"familyNames":[{"familyName":"Takahashi","familyNameLang":"en"}],"givenNames":[{"givenName":"Shinya","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Delchev, Konstantin Vassilev","creatorNameLang":"en"}],"familyNames":[{"familyName":"Delchev","familyNameLang":"en"}],"givenNames":[{"givenName":"Konstantin Vassilev","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Sueda, Taijiro","creatorNameLang":"en"}],"familyNames":[{"familyName":"Sueda","familyNameLang":"en"}],"givenNames":[{"givenName":"Taijiro","givenNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"(c) Hiroshima University Medical Press."}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"Aortic dissection","subitem_subject_scheme":"Other"},{"subitem_subject":"SNP","subitem_subject_scheme":"Other"},{"subitem_subject":"TIMP-1","subitem_subject_scheme":"Other"},{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"While single nucleotide polymorphisms (SNP) have been extensively researched in atherosclerotic aortic aneurysms, there are too few data about acute aortic dissection (AAD). The matrix metalloproteinase regulation system has shown a high biological relevance to the development of aortic aneurysms and AAD. The TIMP-1 c.T372C (rs4898, nt+434) SNP was previously associated with the onset of abdominal aortic and other aneurysms. Therefore, we chose this SNP to search for a connection with AAD and to find its place among the other risk factors. 115 patients with AAD were studied for their TIMP-1 c.T372C genotype by means of conventional restrictase analysis. To confirm the biological relevance of our findings, immunohistochemistry for TIMP-1 was performed on tissue samples from the same patients with AAD and compared with a control group of 23 autopsy cases. The TIMP-1 c.T372C showed a significant difference in allele frequency in the AAD patients compared to the general population (p < 0.0001 for both sexes). This genotype did not show any association with any other co-morbid condition, nor with age. The immunohistochemistry results also showed significantly lower TIMP-1 expression in the dissected aortas. The C allele of TIMP-1 c.T372C shows a strong association with the onset of AAD.","subitem_description_language":"en"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Hiroshima University Medical Press"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_source_identifier":"0018-2052","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA00664312","subitem_source_identifier_type":"NCID"}]},"item_1617187024783":{"attribute_name":"開始ページ","attribute_value_mlt":[{"subitem_start_page":"31"}]},"item_1617187056579":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"37","bibliographicPageStart":"31","bibliographicVolumeNumber":"62","bibliographic_titles":[{"bibliographic_title":"Hiroshima Journal of Medical Sciences"},{"bibliographic_title":"Hiroshima Journal of Medical Sciences"}]}]},"item_1617258105262":{"attribute_name":"item_1617258105262","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-03-18"}],"displaytype":"simple","filename":"HiroshimaJMedSci_62_31.pdf","filesize":[{"value":"399.0 KB"}],"mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hiroshima.repo.nii.ac.jp/record/2013678/files/HiroshimaJMedSci_62_31.pdf"},"version_id":"d9599ab9-de58-42fb-9778-148bcade5933"}]},"item_1732771732025":{"attribute_name":"旧ID","attribute_value":"35027"},"item_title":"TIMP-1 c.T372C Genetic Polymorphism as a Possible Predictor for Acute Aortic Dissection","item_type_id":"40003","owner":"41","path":["1730442249437"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-03-18"},"publish_date":"2023-03-18","publish_status":"0","recid":"2013678","relation_version_is_last":true,"title":["TIMP-1 c.T372C Genetic Polymorphism as a Possible Predictor for Acute Aortic Dissection"],"weko_creator_id":"41","weko_shared_id":-1},"updated":"2025-06-02T03:27:01.675818+00:00"}