{"created":"2025-02-23T06:40:14.394904+00:00","id":2013675,"links":{},"metadata":{"_buckets":{"deposit":"03225948-1167-4dec-b30b-38c95861cb3f"},"_deposit":{"created_by":41,"id":"2013675","owners":[41],"pid":{"revision_id":0,"type":"depid","value":"2013675"},"status":"published"},"_oai":{"id":"oai:hiroshima.repo.nii.ac.jp:02013675","sets":["1727147343679:1730442224523:1730442250208"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"Restoration of IGFBP-rP1 Increases Radiosensitivity and Chemosensitivity in Hormone-refractory Human Prostate Cancer","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Seki, Mitsuhiro","creatorNameLang":"en"}],"familyNames":[{"familyName":"Seki","familyNameLang":"en"}],"givenNames":[{"givenName":"Mitsuhiro","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Teishima, Jun","creatorNameLang":"en"}],"familyNames":[{"familyName":"Teishima","familyNameLang":"en"}],"givenNames":[{"givenName":"Jun","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Mochizuki, Hideki","creatorNameLang":"en"}],"familyNames":[{"familyName":"Mochizuki","familyNameLang":"en"}],"givenNames":[{"givenName":"Hideki","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Mutaguchi, Kazuaki","creatorNameLang":"en"}],"familyNames":[{"familyName":"Mutaguchi","familyNameLang":"en"}],"givenNames":[{"givenName":"Kazuaki","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Yasumoto, Hiroaki","creatorNameLang":"en"}],"familyNames":[{"familyName":"Yasumoto","familyNameLang":"en"}],"givenNames":[{"givenName":"Hiroaki","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Oka, Kiyotaka","creatorNameLang":"en"}],"familyNames":[{"familyName":"Oka","familyNameLang":"en"}],"givenNames":[{"givenName":"Kiyotaka","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Nagamatsu, Hirotaka","creatorNameLang":"en"}],"familyNames":[{"familyName":"Nagamatsu","familyNameLang":"en"}],"givenNames":[{"givenName":"Hirotaka","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Shoji, Koichi","creatorNameLang":"en"}],"familyNames":[{"familyName":"Shoji","familyNameLang":"en"}],"givenNames":[{"givenName":"Koichi","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Matsubara, Akio","creatorNameLang":"en"}],"familyNames":[{"familyName":"Matsubara","familyNameLang":"en"}],"givenNames":[{"givenName":"Akio","givenNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"(c) Hiroshima University Medical Press."}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"IGFBP-rP1","subitem_subject_scheme":"Other"},{"subitem_subject":"Prostate cancer","subitem_subject_scheme":"Other"},{"subitem_subject":"Docetaxel","subitem_subject_scheme":"Other"},{"subitem_subject":"Radiosensitivity","subitem_subject_scheme":"Other"},{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"We previously reported the tumor-suppressive activity of insulin-like growth factor binding protein-related protein 1 (IGFBP-rP1) through induction of apoptosis in human prostate cancer cells. The aim of this study was to investigate the effects of IGFBP-rP1 for radiosensitivity and chemosensitivity in hormone-refractory human prostate PC-3 cancer cells. Five assays were performed using PC-3 cells transfected with IGFBP-rP1 (PC-3rP1) and control cells transfected with an empty vector (PC-3N): PC-3rP1 and PC-3N were compared by clonogenic survival assay, cell cycle analysis and apoptotic assay for radiosensitivity. The number of colonies of PC-3rP1 cells significantly decreased after 4 and 8 Gy of irradiation, compared with those of PC-3N in the clonogenic survival assay. After 16 hr irradiation at 8 Gy, the percentage of apoptotic cells significantly increased in PC-3rP1 compared with PC-3N. Growth of PC-3rP1 was significantly lower than that of PC-3N after docetaxel treatment both in vitro and in vivo. These results indicate that restoration of IGFBP-rP1 to PC-3 cells increases both their radiosensitivity and chemosensitivity.","subitem_description_language":"en"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Hiroshima University Medical Press"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_source_identifier":"0018-2052","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA00664312","subitem_source_identifier_type":"NCID"}]},"item_1617187024783":{"attribute_name":"開始ページ","attribute_value_mlt":[{"subitem_start_page":"13"}]},"item_1617187056579":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"19","bibliographicPageStart":"13","bibliographicVolumeNumber":"62","bibliographic_titles":[{"bibliographic_title":"Hiroshima Journal of Medical Sciences"},{"bibliographic_title":"Hiroshima Journal of Medical Sciences"}]}]},"item_1617258105262":{"attribute_name":"item_1617258105262","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-03-18"}],"displaytype":"simple","filename":"HiroshimaJMedSci_62_13.pdf","filesize":[{"value":"673.3 KB"}],"mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hiroshima.repo.nii.ac.jp/record/2013675/files/HiroshimaJMedSci_62_13.pdf"},"version_id":"04c01c3c-c41e-44c7-a0fd-a9f4129f3213"}]},"item_1732771732025":{"attribute_name":"旧ID","attribute_value":"35024"},"item_title":"Restoration of IGFBP-rP1 Increases Radiosensitivity and Chemosensitivity in Hormone-refractory Human Prostate Cancer","item_type_id":"40003","owner":"41","path":["1730442250208"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-03-18"},"publish_date":"2023-03-18","publish_status":"0","recid":"2013675","relation_version_is_last":true,"title":["Restoration of IGFBP-rP1 Increases Radiosensitivity and Chemosensitivity in Hormone-refractory Human Prostate Cancer"],"weko_creator_id":"41","weko_shared_id":-1},"updated":"2025-06-02T03:26:26.672373+00:00"}