| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
The Valproate Serum Level in Maintenance Therapy for Bipolar Disorder in Japan |
|
言語 |
en |
| 作成者 |
Machino, Akihiko
Jitsuiki, Hiroaki
Okamoto, Yasumasa
Izumitani, Satoru
Kimura, Yasuhiro
Suzuki, Katsuji
Tanaka, Teruaki
Inoue, Takeshi
Koyama, Tsukasa
Wada, Ken
Masaoka, Yukari
Sasaki, Takanobu
Yoshimura, Reiji
Nakamura, Jun
Sumitani, Satsuki
Ohmori, Tetsuro
Yamawaki, Shigeto
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
権利情報 |
(c) Hiroshima University Medical Press. |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Valproate |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Serum valproate level |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Bipolar disorder |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Maintenance therapy |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
|
|
内容記述 |
The appropriate therapeutic serum valproate level in maintenance therapy for bipolar disorder is not well known. We studied the serum valproate levels in seventeen bipolar I and twenty-four bipolar II disorder outpatients who had been treated with stable doses of valproate successfully for at least 12 months as prophylactic therapy. The trough serum valproate levels were 52.2 ± 20.4 μg/ml in bipolar I, and 41.0 ± 18.3 μg/ml in bipolar II disorder patients, respectively. A greater trend towards a higher trough level (p=0.07) was indicated in the bipolar I disorder group. We speculate that these valproate levels may be an approximation to the appropriate valproate levels in maintenance therapy and that there may be a correlation between the level of valproate required for stabilization and the subtype of the bipolar disorder. However, when interpreting these findings, certain limitations to this study?need to be taken into account as follows. The sample size was small. We could not look at a group on valproate that had relapsed and a group that had dropped out of maintenance therapy. Further studies are needed. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Hiroshima University Medical Press |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0018-2052 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00664312 |
| 開始ページ |
|
|
開始ページ |
7 |
| 書誌情報 |
Hiroshima Journal of Medical Sciences
Hiroshima Journal of Medical Sciences
巻 62,
号 1,
p. 7-12,
発行日 2013-03
|
| 旧ID |
35023 |
HiroshimaJMedSci_62_7.pdf (244.0 KB)
