| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Influences of Pyrexia and Age on Theophylline Clearance in Young Children with Asthma |
|
言語 |
en |
| 作成者 |
Imai, Keisuke
Munehisa, Yumiko
Yoshikuni, Yoshiko
Morita, Tadayuki
Nomura, Hiroaki
Kimura, Yasuhiro
Mimaki, Yuichi
Kihira, Kenji
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
権利情報 |
(c) Hiroshima University Medical Press. |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Theophylline |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Children |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Pyrexia |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Clearance |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
|
|
内容記述 |
Fifty hospitalized children with asthmatic bronchitis and bronchial asthma were treated with a continuous intravenous drip infusion of aminophylline. To investigate the pharmacokinetics of theophylline in the presence of pyrexia, patients were divided into two groups based on body temperature: a pyrexia group (≥ 38°C) and a non-pyrexia group (< 38°C). Theophylline clearance was 0.064 ± 0.017 liters/kg/hr in the non-pyrexia group and 0.049 ± 0.010 liters/kg/hr in the pyrexia group. Theophylline clearance in the non-pyrexia and pyrexia groups was 0.044 ± 0.007 liters/kg/hr and 0.030 ± 0.009 liters/kg/hr (≤ 6 months), 0.071 ± 0.011 liters/kg/hr and 0.047 ± 0.008 liters/kg/hr (6 to ≤ 12 months), 0.084 ± 0.012 liters/kg/hr and 0.055 ± 0.006 liters/ kg/hr (1 to ≤ 2 years), and 0.065 ± 0.007 liters/kg/hr and 0.051 ± 0.001 liters/kg/hr (2 to ≤ 3 years), respectively. In all age groups, theophylline clearance of the pyrexia group was significantly less than that of the non-pyrexia group (p < 0.01), showing that there was a significant pharmacokinetic difference in theophylline clearance between the groups. Multivariate statistical analysis showed that theophylline clearance was affected by pyrexia and age. This study showed that the presence of pyrexia decreases theophylline clearance, and that it affects theophylline clearance in an age-dependent manner. Based on the results of this study, dosages should be designed based on the clearance at the time of pyrexia. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Hiroshima University Medical Press |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0018-2052 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00664312 |
| 開始ページ |
|
|
開始ページ |
15 |
| 書誌情報 |
Hiroshima Journal of Medical Sciences
Hiroshima Journal of Medical Sciences
巻 61,
号 1,
p. 15-18,
発行日 2012-03
|
| 旧ID |
35006 |
HiroshimaJMedSci_61_15.pdf (233.0 KB)
