{"created":"2025-02-23T06:38:59.894363+00:00","id":2013633,"links":{},"metadata":{"_buckets":{"deposit":"f4d7854d-1d7a-4d35-be1f-95372d9bbc38"},"_deposit":{"created_by":41,"id":"2013633","owners":[41],"pid":{"revision_id":0,"type":"depid","value":"2013633"},"status":"published"},"_oai":{"id":"oai:hiroshima.repo.nii.ac.jp:02013633","sets":["1727147343679:1730442224523:1730442259272"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"Prognostic Significance of Expression Patterns of EGFR Family, p21 and p27 in High-grade Astrocytoma","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Nabika, Shinya","creatorNameLang":"en"}],"familyNames":[{"familyName":"Nabika","familyNameLang":"en"}],"givenNames":[{"givenName":"Shinya","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kiya, Katsuzo","creatorNameLang":"en"}],"familyNames":[{"familyName":"Kiya","familyNameLang":"en"}],"givenNames":[{"givenName":"Katsuzo","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Satoh, Hideki","creatorNameLang":"en"}],"familyNames":[{"familyName":"Satoh","familyNameLang":"en"}],"givenNames":[{"givenName":"Hideki","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Mizoue, Tatsuya","creatorNameLang":"en"}],"familyNames":[{"familyName":"Mizoue","familyNameLang":"en"}],"givenNames":[{"givenName":"Tatsuya","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kondo, Hiroshi","creatorNameLang":"en"}],"familyNames":[{"familyName":"Kondo","familyNameLang":"en"}],"givenNames":[{"givenName":"Hiroshi","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Katagiri, Masaya","creatorNameLang":"en"}],"familyNames":[{"familyName":"Katagiri","familyNameLang":"en"}],"givenNames":[{"givenName":"Masaya","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Nishisaka, Takashi","creatorNameLang":"en"}],"familyNames":[{"familyName":"Nishisaka","familyNameLang":"en"}],"givenNames":[{"givenName":"Takashi","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Sugiyama, Kazuhiko","creatorNameLang":"en"}],"familyNames":[{"familyName":"Sugiyama","familyNameLang":"en"}],"givenNames":[{"givenName":"Kazuhiko","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kurisu, Kaoru","creatorNameLang":"en"}],"familyNames":[{"familyName":"Kurisu","familyNameLang":"en"}],"givenNames":[{"givenName":"Kaoru","givenNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"(c) Hiroshima University Medical Press."}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"EGFR","subitem_subject_scheme":"Other"},{"subitem_subject":"p27","subitem_subject_scheme":"Other"},{"subitem_subject":"p21","subitem_subject_scheme":"Other"},{"subitem_subject":"High-grade astrocytoma","subitem_subject_scheme":"Other"},{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"The goal of this study was to investigate the relationship among immunohistochemical expression of epithelial growth factor receptor (EGFR) family proteins, p21, p27 and prognosis in patients with high-grade astrocytoma. Expression of EGFR family proteins (c-erbB-1, c-erbB-2, c-erbB-3, c-erbB-4), p21 and p27 and Ki-67 labeling index (LI) were studied in 59 samples of high-grade astrocytoma. Expression of protein levels was analyzed by immunohistochemical staining of formalin-fixed and paraffin-embedded sections. Results were analyzed in relation to age, gender and survival. Overexpression of c-erbB-1, c-erbB-2, c-erbB-3 and c-erbB-4 was found in 40 (67.8%), 17 (28.8%), 3 (5.1 %) and 42 (75.0%) samples, respectively. Similarly, low expression of p21 and p27 was observed in 50 (84.8%) and 27 (45.8%) samples. Mean Ki-67 LI was 17.3 ± 1.1. Cox multiple regression analysis showed that c-erbB-1 (Hazard rate(HR) 1.57, 95% Confidence interval (Cl) 1.08-2.36; p=0.017), c-erbB-4 (HR 1.79, 95%CI 1.20- 2. 7 4; p=0.004) and p27 (HR 0.50, 95%CI 0.30-0.82; p=0.006) were significantly associated with survival. High expression of c-erbB-1 and c-erbB-4 and low expression of p27 were associated with poor prognosis in these patients.","subitem_description_language":"en"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Hiroshima University Medical Press"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_source_identifier":"0018-2052","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA00664312","subitem_source_identifier_type":"NCID"}]},"item_1617187024783":{"attribute_name":"開始ページ","attribute_value_mlt":[{"subitem_start_page":"65"}]},"item_1617187056579":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"70","bibliographicPageStart":"65","bibliographicVolumeNumber":"59","bibliographic_titles":[{"bibliographic_title":"Hiroshima Journal of Medical Sciences"},{"bibliographic_title":"Hiroshima Journal of Medical Sciences"}]}]},"item_1617258105262":{"attribute_name":"item_1617258105262","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-03-18"}],"displaytype":"simple","filename":"HiroshimaJMedSci_59_65.pdf","filesize":[{"value":"1.7 MB"}],"mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hiroshima.repo.nii.ac.jp/record/2013633/files/HiroshimaJMedSci_59_65.pdf"},"version_id":"2808aeda-aaf3-4456-9934-15eaebb75a3a"}]},"item_1732771732025":{"attribute_name":"旧ID","attribute_value":"34983"},"item_title":"Prognostic Significance of Expression Patterns of EGFR Family, p21 and p27 in High-grade Astrocytoma","item_type_id":"40003","owner":"41","path":["1730442259272"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-03-18"},"publish_date":"2023-03-18","publish_status":"0","recid":"2013633","relation_version_is_last":true,"title":["Prognostic Significance of Expression Patterns of EGFR Family, p21 and p27 in High-grade Astrocytoma"],"weko_creator_id":"41","weko_shared_id":-1},"updated":"2025-06-02T03:24:12.469048+00:00"}