| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Efficacy of Latanoprost When Stored at Room Temperature |
|
言語 |
en |
| 作成者 |
Mochizuki, Hideki
Itakura, Hideki
Takamatsu, Michiya
Kiuchi, Yoshiaki
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
権利情報 |
(c) Hiroshima University Medical Press. |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Latanoprost |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Xalatan |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Circadian IOP |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Sub-optimal storage |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
|
|
内容記述 |
We compared the ocular hypotensive effect for 24 hours and the tolerability of latanoprost stored at 4 ℃ and 30℃. Seventeen healthy volunteers were included in this crossover trial. Latanoprost 0.005% (Xalatan) was stored at 4℃ or 30℃ for 4 weeks in the dark. The subjects enrolled to the study were randomly assigned to receive either latanoprost stored at 4 ℃ or that stored at 30℃. The eye drop was applied to the right eye of each subject for 3 days. The left eye served as a control without administration. Slit-lamp biomicroscopy and circadian intra ocular pressure (IOP) curve was performed at Day 3, every 3 hours from 6 pm. This procedure was repeated 7 days after changing the drug from 4 ℃ to 30℃ or vice versa, and application to the left eye for 3 days. Eyes treated with latanoprost, stored both at 4 ℃ and 30℃, achieved statistically significantly lower mean IOPs than untreated eyes at all time points, except at 21 hours treated by the drug stored at 30℃. We subtracted the IOP of eyes receiving latanoprost from the IOP of untreated eyes for each time point to evaluate the efficacy of the eye drops (delta IOP). There were no statistically significant differences between the delta IOPs with the drug stored at 4 ℃ and 30℃. During the study, no subject developed a serious adverse event. These results suggest that latanoprost stored at 30℃ for 4 weeks after opening the bottle remains as effective and safe as latanoprost stored under cold conditions. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Hiroshima University Medical Press |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0018-2052 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00664312 |
| 開始ページ |
|
|
開始ページ |
69 |
| 書誌情報 |
Hiroshima Journal of Medical Sciences
Hiroshima Journal of Medical Sciences
巻 57,
号 2,
p. 69-72,
発行日 2008-06
|
| 旧ID |
34954 |
HiroshimaJMedSci_57_69.pdf (742.3 KB)
