{"created":"2025-02-23T06:37:10.420247+00:00","id":2013571,"links":{},"metadata":{"_buckets":{"deposit":"f05e3870-c8d6-4505-b922-4b5ee263669d"},"_deposit":{"created_by":41,"id":"2013571","owners":[41],"pid":{"revision_id":0,"type":"depid","value":"2013571"},"status":"published"},"_oai":{"id":"oai:hiroshima.repo.nii.ac.jp:02013571","sets":["1727147343679:1730442224523:1730442270970"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"Increased Plasma mRNAs of Placenta-specific 1 (PLAC1) and Glial Cells-missing 1 (GCM1) in Mothers with Pre-eclampsia","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Fujito, Naoya","creatorNameLang":"en"}],"familyNames":[{"familyName":"Fujito","familyNameLang":"en"}],"givenNames":[{"givenName":"Naoya","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Samura, Osamu","creatorNameLang":"en"}],"familyNames":[{"familyName":"Samura","familyNameLang":"en"}],"givenNames":[{"givenName":"Osamu","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Miharu, Norio","creatorNameLang":"en"}],"familyNames":[{"familyName":"Miharu","familyNameLang":"en"}],"givenNames":[{"givenName":"Norio","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Tanigawa, Miho","creatorNameLang":"en"}],"familyNames":[{"familyName":"Tanigawa","familyNameLang":"en"}],"givenNames":[{"givenName":"Miho","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hyodo, Maki","creatorNameLang":"en"}],"familyNames":[{"familyName":"Hyodo","familyNameLang":"en"}],"givenNames":[{"givenName":"Maki","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kudo, Yoshiki","creatorNameLang":"en"}],"familyNames":[{"familyName":"Kudo","familyNameLang":"en"}],"givenNames":[{"givenName":"Yoshiki","givenNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"(c) Hiroshima University Medical Press."}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"Quantitative analysis of placental mRNA","subitem_subject_scheme":"Other"},{"subitem_subject":"Noninvasive prediction markers for preeclampsia","subitem_subject_scheme":"Other"},{"subitem_subject":"Placenta-specific 1 (PLAC1)","subitem_subject_scheme":"Other"},{"subitem_subject":"Glial cells-missing 1 (GCM1)","subitem_subject_scheme":"Other"},{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"In this study we have investigated whether quantitative analysis of placental mRNAs in maternal plasma provides a way to monitor placental status. We measured plasma concentrations of human chorionic gonadotropin /)-subunit (/3hCG) and human placental lactogen (hPL) mRNAs as previously reported mRNAs and pregnancy associated plasma protein A (PAPP-A), placenta-specific 1 (PLACl) and glial cells-missing 1 (GCMl) mRNAs, which have not been measured during the course of normal pregnancy. Firstly, peripheral blood was obtained at various times from healthy pregnant women to clarify the time course of placental mRNAs. Secondly, blood was obtained from women with pre-eclampsia and gestational age-matched controls to examine whether placental mRNAs change in pre-eclampsia. Plasma was separated from these samples for extraction of RNA, followed by reverse transcription polymerse chain reaction analysis. Median concentrations of PLACl and GCMl mRNA in plasma of pre-eclamptic subjects respectively were 1625 and 2141 copies/ml, significantly higher than 195 and 881 copies/ml, the values for controls (Mann-Whitney test, p<0.001). No significant difference was seen in hPL, f3hCG, or PAPP-A mRNA concentration between pre-eclamptic and control groups. Plasma PLACl and GCMl mRNAs appear promising as noninvasively measurable molecular markers for pre-eclampsia.","subitem_description_language":"en"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Hiroshima University Medical Press"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_source_identifier":"0018-2052","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA00664312","subitem_source_identifier_type":"NCID"}]},"item_1617187024783":{"attribute_name":"開始ページ","attribute_value_mlt":[{"subitem_start_page":"9"}]},"item_1617187056579":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2006-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"15","bibliographicPageStart":"9","bibliographicVolumeNumber":"55","bibliographic_titles":[{"bibliographic_title":"Hiroshima Journal of Medical Sciences"},{"bibliographic_title":"Hiroshima Journal of Medical Sciences"}]}]},"item_1617258105262":{"attribute_name":"item_1617258105262","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-03-18"}],"displaytype":"simple","filename":"HiroshimaJMedSci_55_9.pdf","filesize":[{"value":"931.0 KB"}],"mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hiroshima.repo.nii.ac.jp/record/2013571/files/HiroshimaJMedSci_55_9.pdf"},"version_id":"f8818a62-a065-437d-b7f5-3652fca81040"}]},"item_1732771732025":{"attribute_name":"旧ID","attribute_value":"34921"},"item_title":"Increased Plasma mRNAs of Placenta-specific 1 (PLAC1) and Glial Cells-missing 1 (GCM1) in Mothers with Pre-eclampsia","item_type_id":"40003","owner":"41","path":["1730442270970"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-03-18"},"publish_date":"2023-03-18","publish_status":"0","recid":"2013571","relation_version_is_last":true,"title":["Increased Plasma mRNAs of Placenta-specific 1 (PLAC1) and Glial Cells-missing 1 (GCM1) in Mothers with Pre-eclampsia"],"weko_creator_id":"41","weko_shared_id":-1},"updated":"2025-06-02T03:20:17.523968+00:00"}