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V1 Receptor Activation Induced by Hemorrhage and Sympathoinhibition in the Mesentery and Hindquarters of Spontaneously Hypertensive Rats
https://hiroshima.repo.nii.ac.jp/records/2013566
https://hiroshima.repo.nii.ac.jp/records/2013566836f8105-03d7-4ba9-becd-f8604de31508
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
HiroshimaJMedSci_54_93.pdf (578.7 KB)
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| Item type | デフォルトアイテムタイプ_（フル）(1) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2023-03-18 | |||||||||
| タイトル | ||||||||||
| タイトル | V1 Receptor Activation Induced by Hemorrhage and Sympathoinhibition in the Mesentery and Hindquarters of Spontaneously Hypertensive Rats | |||||||||
| 言語 | en | |||||||||
| 作成者 |
Xing, Chi Hong
× Xing, Chi Hong
× Teranishi, Yasuhiro
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| アクセス権 | ||||||||||
| アクセス権 | open access | |||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||
| 権利情報 | ||||||||||
| 権利情報 | Hiroshima University Medical Press | |||||||||
| 主題 | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Regional blood flow | |||||||||
| 主題 | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Hemorrhage | |||||||||
| 主題 | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Ganglionic blockade | |||||||||
| 主題 | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | V1 receptor antagonist | |||||||||
| 主題 | ||||||||||
| 主題Scheme | NDC | |||||||||
| 主題 | 490 | |||||||||
| 内容記述 | ||||||||||
| 内容記述 | The aim of this study was to determine the effects of vasopressin V 1 receptor antagonism on regional hemodynamics in spontaneously hypertensive rats (SHR/Izm). Changes in blood flow in the superior mesenteric artery or terminal aorta were measured in rats with a chronically implanted electromagnetic flowmeter. The combination of a non-hypotensive hemorrhage (0.3 ml/100 g weight) and ganglionic blockade with hexamethonium bromide (C6; 25 mg/kg weight) had no effect on mesenteric resistance. On the other hand, subsequent intravenous administration of a peptide vasopressin V1 receptor antagonist (V1A; 10 μg/kg:[d(CH2)5 1-O Methyl-Tyr2-Arg8]-vasopressin) significantly reduced mesenteric resistance in SHR/Izm but had no effect on hindquarter resistance. Furthermore, the infusion of C6 (after pretreatment with hemorrhage plus V 1A) induced a marked reduction of blood pressure and a significant decrease in superior mesenteric resistance only in SHR/Izm. Thus, we showed an altered reactivity to V1A in the superior mesenteric and/or hindquarter vascular regions of SHR/Izm, suggesting that maintenance of elevated resistance in the mesenteric vascular bed mainly relates to a potential vasopressin- mediated vasoconstriction and that a new sympathetic vasoconstrictor tone is generated within the superior mesenteric vascular bed to compensate for hypotensive intervention (minor hemorrhage plus V 1A) in conscious SHR/Izm. | |||||||||
| 言語 | en | |||||||||
| 出版者 | ||||||||||
| 出版者 | Hiroshima University Medical Press | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | departmental bulletin paper | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
| 収録物識別子 | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 0018-2052 | |||||||||
| 収録物識別子 | ||||||||||
| 収録物識別子タイプ | NCID | |||||||||
| 収録物識別子 | AA00664312 | |||||||||
| 開始ページ | ||||||||||
| 開始ページ | 93 | |||||||||
| 書誌情報 |
Hiroshima Journal of Medical Sciences Hiroshima Journal of Medical Sciences 巻 54, 号 4, p. 93-99, 発行日 2005-12 |
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| 旧ID | 37667 | |||||||||
