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Multi-target Models and their Application to Data Analysis of Cellular Mortality due to Radiation Exposure
https://hiroshima.repo.nii.ac.jp/records/2013552
https://hiroshima.repo.nii.ac.jp/records/201355231a4913c-cef9-440b-9212-c84990c22481
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KJ00004161810.pdf (996.2 KB)
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| Item type | デフォルトアイテムタイプ_（フル）(1) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2023-03-18 | |||||||||
| タイトル | ||||||||||
| タイトル | Multi-target Models and their Application to Data Analysis of Cellular Mortality due to Radiation Exposure | |||||||||
| 言語 | en | |||||||||
| 作成者 |
Arcana, I Made
× Arcana, I Made
× Ohtaki, Megu
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| アクセス権 | ||||||||||
| アクセス権 | open access | |||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||
| 主題 | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Gamma-frailty model | |||||||||
| 主題 | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Miso (fermented soy bean paste) | |||||||||
| 主題 | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Poisson regression model | |||||||||
| 主題 | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Radio protective effects | |||||||||
| 主題 | ||||||||||
| 主題Scheme | NDC | |||||||||
| 主題 | 490 | |||||||||
| 内容記述 | ||||||||||
| 内容記述 | We consider multi-target models for use in analyzing data of the dose-response relationship. The target sizes we are concerned with here are both homogeneous, as assumed in the classical model, and heterogeneous, as simplified using geometric progression. We apply two models for establishing the multi-target models: a Poisson regression model constructed by assuming that the response variable Y follows Poisson distribution, and a gamma-frailty model as a Poisson mixture model derived by adding random common risks having a gamma distribution. Applying these models to experimental data relating the effects of miso fermentation-stages on the survival rate of cells of intestinal crypts of mice exposed to radiation yielded the result that there were substantial frailties associated with all miso fermentation-stages. Short-term and medium-term fermented miso provided similar effects, whereas long-term fermentation had the lowest relative risk value, indicating a significant protection of the crypts against exposure effects. A gamma-frailty model based on heterogeneous target size was more suitably applied when there were at least 3 dead stem cells having 10 target genes. | |||||||||
| 言語 | en | |||||||||
| 出版者 | ||||||||||
| 出版者 | Hiroshima University Medical Press | |||||||||
| 出版者 | ||||||||||
| 出版者 | 国立情報学研究所 | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | departmental bulletin paper | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
| 収録物識別子 | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 0018-2052 | |||||||||
| 収録物識別子 | ||||||||||
| 収録物識別子タイプ | NCID | |||||||||
| 収録物識別子 | AA00664312 | |||||||||
| 開始ページ | ||||||||||
| 開始ページ | 9 | |||||||||
| 書誌情報 |
Hiroshima Journal of Medical Sciences Hiroshima Journal of Medical Sciences 巻 54, 号 1, p. 9-20, 発行日 2005-03 |
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| 旧ID | 17695 | |||||||||
