{"created":"2025-02-23T06:36:35.807210+00:00","id":2013551,"links":{},"metadata":{"_buckets":{"deposit":"712ce5c1-0b2a-42df-af7e-b33b605e8fcc"},"_deposit":{"created_by":41,"id":"2013551","owners":[41],"pid":{"revision_id":0,"type":"depid","value":"2013551"},"status":"published"},"_oai":{"id":"oai:hiroshima.repo.nii.ac.jp:02013551","sets":["1727147343679:1730442224523:1730442274124"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"Intracellular Cytokine Patterns of Peripheral Blood T Cells as a Useful Indicator of Activeness of Crohn's Disease","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ogura, Yoshio","creatorNameLang":"en"}],"familyNames":[{"familyName":"Ogura","familyNameLang":"en"}],"givenNames":[{"givenName":"Yoshio","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Imamura, Yuji","creatorNameLang":"en"}],"familyNames":[{"familyName":"Imamura","familyNameLang":"en"}],"givenNames":[{"givenName":"Yuji","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Murakami, Yoshiaki","creatorNameLang":"en"}],"familyNames":[{"familyName":"Murakami","familyNameLang":"en"}],"givenNames":[{"givenName":"Yoshiaki","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Takesue, Yoshio","creatorNameLang":"en"}],"familyNames":[{"familyName":"Takesue","familyNameLang":"en"}],"givenNames":[{"givenName":"Yoshio","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Yokoyama, Takashi","creatorNameLang":"en"}],"familyNames":[{"familyName":"Yokoyama","familyNameLang":"en"}],"givenNames":[{"givenName":"Takashi","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Sueda, Taijiro","creatorNameLang":"en"}],"familyNames":[{"familyName":"Sueda","familyNameLang":"en"}],"givenNames":[{"givenName":"Taijiro","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hiyama, Eiso","creatorNameLang":"en"}],"familyNames":[{"familyName":"Hiyama","familyNameLang":"en"}],"givenNames":[{"givenName":"Eiso","givenNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"Crohn's disease","subitem_subject_scheme":"Other"},{"subitem_subject":"Cytokine","subitem_subject_scheme":"Other"},{"subitem_subject":"CD45RO","subitem_subject_scheme":"Other"},{"subitem_subject":"Helper T cells","subitem_subject_scheme":"Other"},{"subitem_subject":"Peripheral blood","subitem_subject_scheme":"Other"},{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"Recently, the alteration of peripheral T cells has become a focus of attention in research on Crohn's disease (CD). To examine the characteristics of peripheral T cells in CD patients, we analyzed the expression of a memory T cell marker (CD45RO^<Bright>CD3+) and the cytokine production by peripheral helper and cytotoxic T cells in patients with CD. With the use of monensin to prevent the secretion of cytokines under stimulation, we measured the count of intracellular cytokine-positive cells for production of interferon (IFN)-γ, tumor necrosis factor (TNF)-α, interleukin (IL)-2, IL-4, IL-6, IL-10, and granulocyte-macrophage colony stimulating factor (GM-CSF) in the peripheral T cell population using flow-cytometry. The counts of lymphocytes, T cells, and helper T cells in patients with CD were significantly lower than in normal volunteers. Although no difference in the counts of lymphocytes, total T cells, helper and cytotoxic T cells was observed, the counts of intracellular cytokine producing helper T cells in IFN-γ, TNF-α or GM-CSF were significantly higher in active cases than in quiescent cases. These results suggest that stable CD patients are immunosuppressive, and activation of some kinds of T-cells, especially Thl-associated cytokine producing T-cells, correlate with disease progression. Thl-associated cytokine analysis of peripheral T cells may be one of the useful markers to evaluate the activeness of Crohn's disease.","subitem_description_language":"en"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Hiroshima University Medical Press"},{"subitem_publisher":"国立情報学研究所"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_source_identifier":"0018-2052","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA00664312","subitem_source_identifier_type":"NCID"}]},"item_1617187024783":{"attribute_name":"開始ページ","attribute_value_mlt":[{"subitem_start_page":"1"}]},"item_1617187056579":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2005-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"8","bibliographicPageStart":"1","bibliographicVolumeNumber":"54","bibliographic_titles":[{"bibliographic_title":"Hiroshima Journal of Medical Sciences"},{"bibliographic_title":"Hiroshima Journal of Medical Sciences"}]}]},"item_1617258105262":{"attribute_name":"item_1617258105262","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-03-18"}],"displaytype":"simple","filename":"KJ00004161809.pdf","filesize":[{"value":"1.0 MB"}],"mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hiroshima.repo.nii.ac.jp/record/2013551/files/KJ00004161809.pdf"},"version_id":"7d6be3e4-01b8-4291-bdbd-6586c1137d81"}]},"item_1732771732025":{"attribute_name":"旧ID","attribute_value":"17694"},"item_title":"Intracellular Cytokine Patterns of Peripheral Blood T Cells as a Useful Indicator of Activeness of Crohn's Disease","item_type_id":"40003","owner":"41","path":["1730442274124"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-03-18"},"publish_date":"2023-03-18","publish_status":"0","recid":"2013551","relation_version_is_last":true,"title":["Intracellular Cytokine Patterns of Peripheral Blood T Cells as a Useful Indicator of Activeness of Crohn's Disease"],"weko_creator_id":"41","weko_shared_id":-1},"updated":"2025-06-02T03:18:49.858284+00:00"}