| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Intracellular Cytokine Patterns of Peripheral Blood T Cells as a Useful Indicator of Activeness of Crohn's Disease |
|
言語 |
en |
| 作成者 |
Ogura, Yoshio
Imamura, Yuji
Murakami, Yoshiaki
Takesue, Yoshio
Yokoyama, Takashi
Sueda, Taijiro
Hiyama, Eiso
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Crohn's disease |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Cytokine |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
CD45RO |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Helper T cells |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Peripheral blood |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
|
|
内容記述 |
Recently, the alteration of peripheral T cells has become a focus of attention in research on Crohn's disease (CD). To examine the characteristics of peripheral T cells in CD patients, we analyzed the expression of a memory T cell marker (CD45RO^<Bright>CD3+) and the cytokine production by peripheral helper and cytotoxic T cells in patients with CD. With the use of monensin to prevent the secretion of cytokines under stimulation, we measured the count of intracellular cytokine-positive cells for production of interferon (IFN)-γ, tumor necrosis factor (TNF)-α, interleukin (IL)-2, IL-4, IL-6, IL-10, and granulocyte-macrophage colony stimulating factor (GM-CSF) in the peripheral T cell population using flow-cytometry. The counts of lymphocytes, T cells, and helper T cells in patients with CD were significantly lower than in normal volunteers. Although no difference in the counts of lymphocytes, total T cells, helper and cytotoxic T cells was observed, the counts of intracellular cytokine producing helper T cells in IFN-γ, TNF-α or GM-CSF were significantly higher in active cases than in quiescent cases. These results suggest that stable CD patients are immunosuppressive, and activation of some kinds of T-cells, especially Thl-associated cytokine producing T-cells, correlate with disease progression. Thl-associated cytokine analysis of peripheral T cells may be one of the useful markers to evaluate the activeness of Crohn's disease. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Hiroshima University Medical Press |
| 出版者 |
|
|
出版者 |
国立情報学研究所 |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0018-2052 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00664312 |
| 開始ページ |
|
|
開始ページ |
1 |
| 書誌情報 |
Hiroshima Journal of Medical Sciences
Hiroshima Journal of Medical Sciences
巻 54,
号 1,
p. 1-8,
発行日 2005-03
|
| 旧ID |
17694 |
KJ00004161809.pdf (1.0 MB)
