| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Comparative Benefit of Preemptively Applied Thiopental for Propofol Injection Pain : the advantage over lidocaine |
|
言語 |
en |
| 作成者 |
Azma, Toshiharu
Kawai, Kazumi
Tamura, Hideki
Okada, Kuniko
Okida, Motoichi
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Thiopental |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Lidocaine |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Propofol |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Pain on injection |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
|
|
内容記述 |
Propofol is one of the most frequently applied intravenous anesthetics for the induction of general anesthesia. However, pain on injection of this agent is a considerable problem in daily anesthesia practice because of its severity. Administration of lidocaine prior to propofol injection is a standard technique for reducing the pain on injection. However, this method provides insufficient pain relief. To evaluate whether pretreatment with an ultra-short acting barbiturate, thiopental, is more effective than with lidocaine, a randomized and single-blinded trial was conducted. Patients (20-65 years old, n=137) were allocated into six groups, and applied with physiological saline, thiopental (25, 50, 75, or 100mg), or lidocaine (40mg) at 30 second prior to propofol injection (1mg/kg, 1200ml/h). The patient was interviewed about the degree of pain just after propofol was totally injected. Both thiopental (≧25mg) and lidocaine decreased the severity of pain in comparison with physiological saline as evaluated by a six-graded pain score. Lidocaine failed to influence the incidence of pain (from 86% to 55%), although thiopental significantly decreased it to 40% (25mg), 21% (50mg), 12% (50mg), and 0% (100mg), respectively. Thiopental (≧50mg) decreased both the severity and incidence of pain more effectively than lidocaine. A Hill plot analysis of these data, after rearrangement by patient's body weight, estimated that the half-effective dose (ED_<50>) and the ED_<99> of this drug to block pain on injection of propofol were 0.6 and 1.4mg/kg, respectively. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Hiroshima University Medical Press |
| 出版者 |
|
|
出版者 |
国立情報学研究所 |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0018-2052 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00664312 |
| 開始ページ |
|
|
開始ページ |
13 |
| 書誌情報 |
Hiroshima Journal of Medical Sciences
Hiroshima Journal of Medical Sciences
巻 53,
号 1,
p. 13-16,
発行日 2004-03
|
| 旧ID |
17687 |
KJ00004267993.pdf (522.8 KB)
