| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
X-rays Induce Dose-dependent and Cell Cycle-independent Accumulation of p21sdi1/WAF1 |
|
言語 |
en |
| 作成者 |
Tsuyama, Naohiro
Ide, Toshinori
Noda, Asao
Iwamoto, Keisuke S.
Mizuno, Terumi
Kyoizumi, Seishi
Seyama, Toshio
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
X-irradiation |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
p21sdi1/WAF1 |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
|
|
内容記述 |
Cell cycle arrest at the G1 checkpoint is governed by a function ofwild-typep53. We assessed the behavior of the sdi1 gene, which codes for a 21kDa potent inhibitor of cdk/cyclins, after X-irradiation. X-irradiation induced sdi1 mRNA accumulation and G1 arrest only in cells possessing wild-type p53. Elevation of p21sdi1/WAF1 was preceded by p53 accumulation, which occurred despite p53 mRNA constancy in normal cells growing in the log phase. The quantity of accumulated p53 and p21sdi1/WAF1 was radiation dose dependent. A decrease in the S phase cell population in normal cells observed after irradiation reached a minimum at less-than-maximum levels of p53 and p21sdi1/WAF1 Furthermore, an accumulation of p53 and p21sdi1/WAF1 was also observed when cells were synchronized in the G0, G1 and S phase and X-irradiated. These results indicated that an X-ray induced p53 and p21sdi1/WAF1 accumulation mechanism exists throughout the cell cycle, and that the signal strength induced by X-irradiation is dose-dependent. |
|
言語 |
en |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
This publication is based on research performed at the Radiation Effects Research Foundation (RERF), Hiroshima and Nagasaki, Japan and is supported in part by Grants-in-Aid (S7-l) for Cancer Research from the Ministry of Health and Welfare. |
| 出版者 |
|
|
出版者 |
Hiroshima University Medical Press |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0018-2052 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00664312 |
| 開始ページ |
|
|
開始ページ |
1 |
| 書誌情報 |
Hiroshima Journal of Medical Sciences
Hiroshima Journal of Medical Sciences
巻 50,
号 1,
p. 1-7,
発行日 2001-03
|
| 旧ID |
37679 |
HiroshimaJMedSci_50_1.pdf (725.0 KB)
