| アイテムタイプ |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Assessment of a New Silicone Tri-leaflet Valve Seamlessly Assembled with Blood Chamber for a Low-cost Ventricular Assist Device |
|
言語 |
en |
| 作成者 |
Hirai, Shinji
Fukunaga, Shintaro
Sueshiro, Masafumi
Watari, Masanobu
Sueda, Taijiro
Matsuura, Yuichiro
|
| アクセス権 |
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|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Silicone tri-leaflet valve |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Silicone blood chamber |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Ventricular assist device |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
|
|
内容記述 |
We have developed a practical, low-cost ventricular assist device (VAD) comprising a newly designed blood chamber with a silicone lenticular sac and two silicone tri-leaflet valves (STV), made en bloc. This new VAD is seamless, can be made cost-effectively and assembled with the blood chamber and valve as one body. This novel design should reduce the incident of thrombus formation because of the absence of a junction at the connecting ring and because of the use of flexible silicone materials which have both antithrombogenecity and biocompatibility. In in vitro hemodynamics testing, a batch of 3 consecutively manufactured V ADs with STV s underwent hydrodynamic functional testing. These showed less regurgitation, a lower value of water hammer phenomenon, and a slightly greater pressure gradient across the valves than a mechanical valve (MV) [Björk-Shiley monostrut valve]. The flow and pulsatile efficiency were adequate and similar to that of a VAD with MVs. In in vitro durability and hemolysis tests, a V AD with STV functioned well for 54 days and showed similar hemolytic profiles to a V AD with MVs. In an in vivo acute experiment using an adult sheep, our device was promblem-free providing sufficient output as a left ventricular assist device (LVAD). Although it will be necessary to decrease the pressure gradient across this STV in the future, our device showed efficient performance as a practical and cost-effective V AD for short term use. |
|
言語 |
en |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
This work was supported in part by the Tsuchiya Foundation and by a Research Grant for Cardiovascular Diseases (7A-1) from the Ministry of Health and Welfare, Japan |
| 出版者 |
|
|
出版者 |
Hiroshima University Medical Press |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0018-2052 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00664312 |
| 開始ページ |
|
|
開始ページ |
47 |
| 書誌情報 |
Hiroshima Journal of Medical Sciences
Hiroshima Journal of Medical Sciences
巻 47,
号 2,
p. 47-55,
発行日 1998-06
|
| 旧ID |
37792 |
HiroshimaJMedSci_47_47.pdf (1.4 MB)
