{"created":"2025-02-23T06:32:00.963324+00:00","id":2013393,"links":{},"metadata":{"_buckets":{"deposit":"93c44c27-fb07-4635-9f90-ae49d624e682"},"_deposit":{"created_by":41,"id":"2013393","owners":[41],"pid":{"revision_id":0,"type":"depid","value":"2013393"},"status":"published"},"_oai":{"id":"oai:hiroshima.repo.nii.ac.jp:02013393","sets":["1727147343679:1730442224523:1730442306263"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"Histological Progression of Follicular Lymphoma Associated with p53 Mutation and Rearrangement of the C-MYC Gene","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Takimoto, Yasuo","creatorNameLang":"en"}],"familyNames":[{"familyName":"Takimoto","familyNameLang":"en"}],"givenNames":[{"givenName":"Yasuo","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Takafuta, Toshiro","creatorNameLang":"en"}],"familyNames":[{"familyName":"Takafuta","familyNameLang":"en"}],"givenNames":[{"givenName":"Toshiro","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Imanaka, Fumio","creatorNameLang":"en"}],"familyNames":[{"familyName":"Imanaka","familyNameLang":"en"}],"givenNames":[{"givenName":"Fumio","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kuramoto, Atsushi","creatorNameLang":"en"}],"familyNames":[{"familyName":"Kuramoto","familyNameLang":"en"}],"givenNames":[{"givenName":"Atsushi","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Sasaki, Naomi","creatorNameLang":"en"}],"familyNames":[{"familyName":"Sasaki","familyNameLang":"en"}],"givenNames":[{"givenName":"Naomi","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Nanba, Koji","creatorNameLang":"en"}],"familyNames":[{"familyName":"Nanba","familyNameLang":"en"}],"givenNames":[{"givenName":"Koji","givenNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"Follicular Lymphoma","subitem_subject_scheme":"Other"},{"subitem_subject":"Transformation","subitem_subject_scheme":"Other"},{"subitem_subject":"BCL2","subitem_subject_scheme":"Other"},{"subitem_subject":"p53","subitem_subject_scheme":"Other"},{"subitem_subject":"C-MYC","subitem_subject_scheme":"Other"},{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"Follicular lymphoma is a low grade malignant lymphoma. However, some follicular lymphomas undergo histological transformation into higher grade malignant lymphomas. We recently encountered a diffuse large cell lymphoma which seemed to have progressed from a follicular lymphoma and which finally transformed into a small non-cleaved lymphoma. Each stage of the histological transformation was accompanied by increasing clinical grades of malignancy. It was suspected that in our patient a follicular lymphoma initially developed due to rearrangement of the BCL2 gene, and then underwent histological transformation into a diffuse large cell lymphoma, which was associated with p53 mutation. Subsequent rearrangement of C-MYC promoted the histological transformation of this diffuse large cell lymphoma into a small non-cleaved lymphoma. Our findings indicate that p53 mutation and rearrangement of C-MYC are involved in the histological transformation of follicular lymphomas into more advanced lymphomas.","subitem_description_language":"en"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Hiroshima University Medical Press"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_source_identifier":"0018-2052","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA00664312","subitem_source_identifier_type":"NCID"}]},"item_1617187024783":{"attribute_name":"開始ページ","attribute_value_mlt":[{"subitem_start_page":"69"}]},"item_1617187056579":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1996-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"73","bibliographicPageStart":"69","bibliographicVolumeNumber":"45","bibliographic_titles":[{"bibliographic_title":"Hiroshima Journal of Medical Sciences"},{"bibliographic_title":"Hiroshima Journal of Medical Sciences"}]}]},"item_1617258105262":{"attribute_name":"item_1617258105262","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-03-18"}],"displaytype":"simple","filename":"HiroshimaJMedSci_45_69.pdf","filesize":[{"value":"738.6 KB"}],"mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hiroshima.repo.nii.ac.jp/record/2013393/files/HiroshimaJMedSci_45_69.pdf"},"version_id":"0f16e876-f3eb-4612-8288-c904626b4e5f"}]},"item_1732771732025":{"attribute_name":"旧ID","attribute_value":"37843"},"item_title":"Histological Progression of Follicular Lymphoma Associated with p53 Mutation and Rearrangement of the C-MYC Gene","item_type_id":"40003","owner":"41","path":["1730442306263"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-03-18"},"publish_date":"2023-03-18","publish_status":"0","recid":"2013393","relation_version_is_last":true,"title":["Histological Progression of Follicular Lymphoma Associated with p53 Mutation and Rearrangement of the C-MYC Gene"],"weko_creator_id":"41","weko_shared_id":-1},"updated":"2025-06-02T03:08:10.605132+00:00"}